| 练德幸,寇珊珊,陆见霏,晁俊,朱仔运,张庆召,侯长松.90Y树脂微球治疗患者尿液中90Y放射性活度检测和分析[J].中华放射医学与防护杂志,2022,42(6):460-463 |
| 90Y树脂微球治疗患者尿液中90Y放射性活度检测和分析 |
| Measurement and analysis of 90Y radioactivity in urine of patients treated with 90Y resin microspheres |
| 投稿时间：2022-03-28 |
| DOI：10.3760/cma.j.cn112271-20220328-00125 |
| 中文关键词: 90Y树脂微球 排泄尿液 放射性活度 |
| 英文关键词:90Y resin microspheres Urinary excretion Radioactivity |
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| 中文摘要: |
| 目的 研究患者接受90Y树脂微球选择性内放射治疗(SIRT)后48 h内所排泄尿液中90Y的放射性活度，为术后患者排泄物的管理提供建议。方法 收集3名患者在术后0~24 h和24~48 h两个时间段内排泄的尿液，并对尿液中的90Y放射性活度进行检测和分析。结果 3名患者术后0~24 h和24~48 h尿液中的90Y放射性活度排泄量分别为(1 266±258)kBq/GBq和(140±106)kBq/GBq，90Y放射性活度浓度分别为(640±113)kBq/L和(53±12)kBq/L。结论 90Y树脂微球治疗术后肝癌患者0~24 h排泄尿液中的90Y放射性活度比24~48 h高。术后患者可通过增加排泄尿量的方式来加速排出体内游离的90Y；患者住院期间的排泄物应按照HJ 1188-2020《核医学辐射防护与安全要求》的要求处理。 |
| 英文摘要: |
| Objective To evaluate 90Y activity concentration in renal excretions during the first 48 hours after being treated with 90Y resin microspheres seleceive internal radiation therapy(SIRI) and to provide advice on the management of patient excreta after surgery.Methods After surgery, urine excreted from 3 patients during 0-24 h and 24-48 h was collected respectively, and the 90Y activity concentration in urine was tested and analyzed.Results 90Y radioctivity in the urine excreted from 3 patients after surgery was (1 266±258)kBq/GBq during 0-24 h and (140±106) kBq/GBq during 24-48 h, respectively, and 90Y activity concentration were (640±113) kBq/L during 0-24 h and (53±12) kBq/L during 24-48 h.Conclusions 90Y radioactivity in patient′s urine excreted at 1 d was about 10 times higher than that at 2 d. After surgery, patients can accelerate the reduction of free 90Y activity by increasing excretion. Urine excreted by the patients during hospitalization should be handled in accordance with the requirements of the national standard HJ 1188-2021 Radiation protection and safety requirements for nuclear medicine. |
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