| 李桃生,李文艺,陆婷婷,徐照.纳剂量学测量与计算的研究进展[J].中华放射医学与防护杂志,2021,41(10):784-789 |
| 纳剂量学测量与计算的研究进展 |
| Current status of of nanodosimetry |
| 投稿时间：2020-12-21 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.10.011 |
| 中文关键词: 纳剂量学 电离簇 电离簇概率分布 纳剂量计 |
| 英文关键词:Nanodosimetry Ionizing cluster size Probability distribution of ionizing cluster Nanodosimeter |
| 基金项目:国家重点研发计划资助（2020YFB1901900） |
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| 中文摘要: |
| 纳剂量学是在微剂量学研究基础上发展起来的一门新型学科，从粒子径迹结构特征出发，研究在一个特体积内产生的电离对数目概率分布以表征DNA链损伤程度，逐步形成了以电离簇、电离簇概率分布和累积概率分布等为概念可以测量的纳剂量学量，并试图解释纳剂量学量与DNA链的辐射损伤和修复之间的关系。本文在回顾现行的纳剂量学测量方法和计算方法的基础上，对纳剂量学的研究发展趋势及其应用前景进行归纳和总结，并提出了纳剂量学的未来研究方向。 |
| 英文摘要: |
| Nanodosimetry, a new discipline developed on the basis of microdosimetry, is based on the structural characteristics of particle tracks and studies on the probability distribution of ionization pairs in a specific volume to characterize the damage degree of DNA strand. Now nanodosimetric quantities, which may be measured, gradually form the concept such as ionization cluster size, ionizing cluster size distribution and complementary cumulative probability distribution etc. This paper aims to establish and explain the relationship between nanodosimetry and DNA damage and repair. On the basis of reviewing the current measurement and calculation method of nanodosimetry, this paper summarized the development trend and application prospect of nanodosimetry, and put forward the future research direction of nanodosimetry. |
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