| 吕玉民,韩林,李杰,等.染色体易位分析在回顾性生物剂量重建中的研究进展[J].中华放射医学与防护杂志,2021,41(9):705-710.Lyu Yumin,Han Lin,Li Jie,et al.Research progress of chromosome translocation analysis in retrospective biological dose reconstruction[J].Chin J Radiol Med Prot,2021,41(9):705-710 |
| 染色体易位分析在回顾性生物剂量重建中的研究进展 |
| Research progress of chromosome translocation analysis in retrospective biological dose reconstruction |
| 投稿时间：2021-02-23 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.09.012 |
| 中文关键词: 电离辐射 染色体易位 生物剂量重建 |
| 英文关键词:Ionizing radiation Chromosome translocation Retrospective biodosimetry |
| 基金项目:河南省科技攻关计划项目（142102310086）；河南省医学科技攻关计划项目（LHGJ20190815） |
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| 中文摘要: |
| 外周血淋巴细胞染色体易位分析用于日本原爆幸存者、早先核与辐射事故受照者回顾性剂量重建已有近40年的发展史，其应用价值已得到国际学界的广泛认可。随着mFISH、dGH等分子细胞遗传学技术的发展，国际上更多关注的是受到长期慢性低剂量暴露的放射工作人员、早年参加核爆炸实验的退伍军人和医疗照射受照者等暴露人群的生物剂量的估算与重建，并在近年来取得了明显的突破与进展。为此，本文对染色体易位指标在这些领域的研究进展进行综述，以期为针对该类人群开展回顾性生物剂量估算研究提供参考。 |
| 英文摘要: |
| The application of chromosome translocation to retrospective biodosimetry for A-bomb survivors, the victims previously exposed to nuclear/radiation accident has experienced nearly 40 years of development. Retrospective biodosimetry was internationally paid close attention to radiation workers, exposed atomic veterans and medical exposure subjects, respectively, along with the development of molecular cytogenetic technology such as mFISH and cGH. And the remarkable breakthrough and progress have been made in recent years. This paper reviews the progress of translocation indicator as retrospective biodosimetry for the subjects, in order to provide a reference for retrospective dose estimation based on translocation analysis. |
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