| 万志杰,赵松韵,杨彦勇,等.基因修饰的间充质干细胞在放射性肺损伤治疗中的实验研究进展[J].中华放射医学与防护杂志,2021,41(8):595-601.Wan Zhijie,Zhao Songyun,Yang Yanyong,et al.Experimental research progress of genetically modified mesenchymal stem cells in the treatment of radiation-induced lung injury[J].Chin J Radiol Med Prot,2021,41(8):595-601 |
| 基因修饰的间充质干细胞在放射性肺损伤治疗中的实验研究进展 |
| Experimental research progress of genetically modified mesenchymal stem cells in the treatment of radiation-induced lung injury |
| 投稿时间：2021-04-27 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.08.006 |
| 中文关键词: 间充质干细胞 基因修饰 放射性肺损伤 肺纤维化 放射性肺炎 |
| 英文关键词:Mesenchymal stem cells Genetic modification Radiation-induced lung injury Pulmonary fibrosis Radiation pneumonia |
| 基金项目:国家自然科学基金（31670861）；军事医学创新工程课题（18CXZ008） |
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| 中文摘要: |
| 放射性肺损伤是胸部恶性肿瘤放疗、核事故重症损伤的常见并发症，目前缺乏有效的治疗手段。间充质干细胞（MSCs）是具有多向分化潜能的细胞群，其通过归巢至损伤部位并分化成受损组织、分泌细胞因子和免疫调节起到防护肺组织辐射损伤的作用。此外，通过对间充质干细胞进行基因修饰，使其不仅具有MSCs的主要特性，而且能够高效稳定表达或敲低某些目的基因，从而增强或降低间充质干细胞对各种生理刺激的敏感性，加强其在放射性肺损伤中治疗的疗效，为临床治疗提供了新思路和新途径。本文就近年来相关进展进行综述。 |
| 英文摘要: |
| Radiation-induced lung injury is a common complication of thoracic malignant tumor radiotherapy and severe nuclear accident injury. Currently, there is no effective treatment on this injury. Mesenchymal stem cells (MSCs) are a group of cells with multi-directional differentiation potential and they can protect lung tissue from radiation damage by homing to the injured site and differentiating to the damaged tissues,secreting cytokines and immune regulation. Further,the genetically modifying mesenchymal stem cells have not only the main characteristics of MSCs, but also can efficiently and stably express or knock down a certain of target genes,thereby enhancing or reducing the sensitivity of mesenchymal stem cells to various physiological stimulus and enhancing its therapeutic effect in radiation-induced lung injury, providing new ideas and new strategies for clinical treatment. This paper reviewed the relevant research progress in recent years. |
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