| 张子琪,龙伟,徐文清.肠道干细胞在放射性肠损伤防护中的作用[J].中华放射医学与防护杂志,2021,41(8):579-586.Zhang Ziqi,Long Wei,Xu Wenqing.Role of intestinal stem cells in prevention of radiation-induced intestinal injury[J].Chin J Radiol Med Prot,2021,41(8):579-586 |
| 肠道干细胞在放射性肠损伤防护中的作用 |
| Role of intestinal stem cells in prevention of radiation-induced intestinal injury |
| 投稿时间：2021-01-21 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.08.004 |
| 中文关键词: 放射性肠损伤 肠道干细胞 肠道辐射防护 防护药物 |
| 英文关键词:Radiation-induced intestinal injury Intestinal stem cells(ISCs) Intestinal radiation protection Protective agents |
| 基金项目:军队后勤研究项目（AEP17J001）；江苏省大学生创新创业训练项目（201910285045Z）。 |
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| 中文摘要: |
| 目前，对于电离辐射（ionizing radiation，IR）引起的放射性肠损伤尚无有效的治愈方法，临床上只能采用对症缓解治疗。肠道干细胞（intestinal stem cells，ISCs）更新能力强，是重构受损小肠结构的重要细胞，促进肠道干细胞数量和功能的恢复已是当前治疗放射性胃肠综合征的研究热点。本文从肠道干细胞的分类、干细胞的调节机制以及具有调控干细胞损伤、凋亡、修复作用的药物等方面介绍了ISCs在放射性肠损伤防护中的重要作用以及其临床应用意义，为未来肠道干细胞在辐射防护中的作用研究提供参考。 |
| 英文摘要: |
| At present, there is no effective treatment method of radiation-induced intestinal injury. Clinically, only symptomatic remission therapy can be used. Intestinal stem cells (ISCs) have strong renewal ability, which is an important part of intestinal structure regeneration. To promote the recovery of the number and function of ISCs has been a research hotspot in the treatment of radiation gastrointestinal syndrome. This article introduces the important role of ISCs in the protection of radiation-induced intestinal injury and its clinical application significance from the classification and regulatory mechanism of ISCs, and drugs that regulate the damage, apoptosis and repair of stem cells, so as to provide reference for the future research on the role of intestinal stem cells in radiation protection. |
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