| 殷娅茹,杨露勋,刘晶,卢丙慧,李蓉.外泌体在放射医学中的应用与机制研究进展[J].中华放射医学与防护杂志,2021,41(7):547-551 |
| 外泌体在放射医学中的应用与机制研究进展 |
| Research progress in the application of exosomes in radiological medicine and underlying mechanisms |
| 投稿时间：2021-02-05 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.07.014 |
| 中文关键词: 外泌体 辐射 旁效应 放射性损伤 肿瘤 |
| 英文关键词:Exosomes Radiation Bystander effect Radiation injury Tumor |
| 基金项目:国家自然科学基金（81773364）；四川省自然基金重点项目（2017SZ0004）；全军后勤科研重大项目（AWS17J007） |
|
| 摘要点击次数: 1878 |
| 全文下载次数: 974 |
| 中文摘要: |
| 核能在军事、医疗、科研和工农业等各个领域应用广泛，在发生事故时可能存在对机体的辐射损伤。目前对重度以上骨髓型放射病的治疗效果依然不理想。外泌体是由活细胞分泌的、大小为30~130 nm的小囊泡，可携带包括蛋白质、RNA、DNA等多种活性物质，是细胞间通讯的重要媒介。外泌体中的内含物不仅可用于辐射损伤的生物标记物，还可用于辐射损伤的治疗。本文对外泌体在放射医学中的应用和机制等研究进展进行了综述。 |
| 英文摘要: |
| Nuclear energy is widely used in various fields such as military, medicine, scientific research, industry and agriculture.Nuclear accident may lead to radiation damage to the bodyofpractitioners. At present, the treatment of severe bone marrow radiation sickness is still not ideal.Exosomes are small vesicles with a size of 30-130 nm secreted by living cells and carry a variety of active substances including protein, RNA, DNA, which isimportant medium of intercellular communication.The contents of exosomes can be used not only as biomarkers of radiation damage, but also for the treatment of radiation damage. This article reviewsthe research progress of the application of exosomes in radiological medicine and underlying mechanisms. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |