| 李雯,潘继元,李毅,任宏涛,王亚利.盆腔放疗后功能不全性骨折的研究进展[J].中华放射医学与防护杂志,2021,41(6):469-474 |
| 盆腔放疗后功能不全性骨折的研究进展 |
| Research progress in insufficient fracture after pelvic radiotherapy |
| 投稿时间：2020-05-20 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.06.013 |
| 中文关键词: 盆腔肿瘤 放射治疗 盆腔功能不全性骨折 |
| 英文关键词:Pelvic tumor Radiotherapy Pelvic insufficiency fracture (PIF) |
| 基金项目:国家自然科学基金（81141097） |
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| 摘要点击次数: 1939 |
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| 中文摘要: |
| 盆腔放疗是大部分盆腔肿瘤的一种治疗方式，盆腔功能不全性骨折（PIF）是盆腔放疗的远期并发症。本篇综述对骨盆功能不全性骨折的研究进展进行了总结和讨论，其发病机制主要与成骨细胞被抑制有关，危险因素有老年、绝经后状态、缺乏激素替代治疗、高分娩次数、吸烟史、低体质量指数（BMI）、并发类风湿性关节炎、并发糖尿病、高剂量率腔内近距离治疗（HDR-ICBT）以及高放疗剂量等，目前尚无有效药物用于预防和治疗。PIF一旦延迟诊断或误诊可引起严重的后果，因此需要更进一步的研究来指导临床工作。 |
| 英文摘要: |
| Pelvic radiotherapy is a way for treatment of most pelvic tumors, of which the pelvic insufficiency fracture (PIF) is a long-term complication. In this review, research progress of pelvic insufficiency fracture is summarized and discussed. The pathogenesis of PIF is mainly about inhibition of osteoblasts and the risk factors of PIF include old age, postmenopausal status, absence of hormonal replacement therapy, high number of births, smoking history, low body mass index (BMI), concurrent rheumatoid arthritis, concurrent diabetes mellitus, intracavitary brachytherapy of the high dose rate (HDR-ICBT), high dose of radiotherapy, etc. Effective drugs for prevention or treatment of PIF have not been found yet. Delayed diagnosis and misdiagnosis of PIF can cause serious consequences. As a result, further studies are needed to guide clinical work. |
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