| 高洁,魏殿军,刘鉴峰,任春华.组蛋白去乙酰化酶抑制剂用于放疗增敏的分子机制研究进展[J].中华放射医学与防护杂志,2021,41(6):465-468 |
| 组蛋白去乙酰化酶抑制剂用于放疗增敏的分子机制研究进展 |
| Research progress in the molecular mechanisms of histone deacetylase inhibitors for radiosensitization |
| 投稿时间：2020-05-07 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.06.012 |
| 中文关键词: 放射治疗 放疗增敏 组蛋白去乙酰化酶抑制剂 选择性杀伤作用 |
| 英文关键词:Radiotherapy Radiosensitization Histone deacetylase inhibitors Selective killing effect |
| 基金项目:国家自然科学基金（52073307，81722026）；天津市自然科学基金（18JCQNJC13600） |
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| 中文摘要: |
| 放射治疗是目前临床上最常用的治疗癌症的手段之一，但其仍存在辐射剂量高、正常组织不良反应大，以及肿瘤细胞的放疗耐受等缺点。因此，寻求安全有效的放疗增敏剂以提高肿瘤细胞对辐射的敏感性一直是放疗研究的热点。组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitors，HDACIs）是一类表观遗传学修饰剂，除了其固有的抗癌特性外，还能调节肿瘤细胞对电离辐射和紫外线辐射敏感性。本文在查阅文献基础上，重点阐述了HDACIs增强肿瘤细胞辐射敏感性的不同分子机制以及对肿瘤细胞的选择性杀伤作用。 |
| 英文摘要: |
| Radiotherapy is one of the most commonly used and effective method to treat malignant tumors in clinical practice. However, there are still some limitations including high radiotherapy doses, harmful side effects on normal tissues, and radiation resistance of tumor cells. Therefore, seeking safe and effective radiotherapy sensitizers to improve radiation sensitivity of tumor cells has been focused for a long time. Histone deacetylase inhibitors (HDACIs), as a kind of epigenetic modifiers, can regulate the sensitivity of tumor cells to ionizing radiation and ultraviolet radiation in addition to the inherent anticancer characteristics. This article reviewed the molecular mechanisms of HDACIs in enhancing radiation sensitivity and by selectively killing tumor cells. |
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