| 邢海群,朱文佳,董诚岩,等.肝胆肿瘤患者68Ga-FAPI-04 PET显像的内照射剂量及分布研究[J].中华放射医学与防护杂志,2021,41(4):293-298.Xing Haiqun,Zhu Wenjia,Dong Chengyan,et al.Radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET in patients with hepatobiliary tumor[J].Chin J Radiol Med Prot,2021,41(4):293-298 |
| 肝胆肿瘤患者68Ga-FAPI-04 PET显像的内照射剂量及分布研究 |
| Radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET in patients with hepatobiliary tumor |
| 投稿时间：2020-09-23 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.010 |
| 中文关键词: 68Ga-FAPI-04 PET/CT 肝胆肿瘤 内照射剂量 生物分布 |
| 英文关键词:68Ga-FAPI-04 PET/CT Hepatobiliary tumor Radiation dosimetry Biodistribution |
| 基金项目:国家自然科学基金（U1803124）；湖南省自然科学基金（2019JJ40396） |
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| 中文摘要: |
| 目的 评估68Ga-FAPI-04 PET/CT检查在肝胆肿瘤患者中的内照射剂量及生物分布。方法 本研究纳入因肝脏占位于北京协和医院接受PET/CT检查的6例患者，经静脉注射68Ga-FAPI-04（170.57 ±14.43） MBq后分别于第3、10、15、20、30和60 min进行全身显像。观察显像剂的生物分布；手动勾画感兴趣区；所有靶器官的内照射剂量应用OLINDA/EXM软件计算。结果 68Ga-FAPI-04在肝脏内放射性本底消退较快，在肿瘤组织内放射性摄取较为稳定，病灶平均SUVmax在注射后20 min达到最大（13.87 ±2.55）；病灶平均靶本比逐渐升高，在注射后30 min达到最大（10.09 ±8.17）。1次68Ga-FAPI-04 PET/CT扫描的全身有效剂量为（0.020 ±0.002） mSv/MBq，吸收剂量最高的器官是膀胱壁，为（0.146 ±0.035） mSv/MBq。结论 68Ga-FAPI-04与18F-FDG全身有效剂量相近；肿瘤摄取快速，肝脏背景低，且不受血糖水平影响，有望成为潜在的肝胆肿瘤PET/CT显像药物。 |
| 英文摘要: |
| Objective To investigate the radiation dosimetry and biodistribution of 68Ga-FAPI-04 PET/CT in patients with hepatobiliary tumor. Methods A total of six patients with hepatic lesions who underwent PET/CT examination in Peking Union Medical College Hospital were enrolled. After intravenous injection of radiotracer 68Ga-FAPI-04 at (170.57 ±14.43) MBq, whole-body imaging were performed at the time points of 3, 10, 15, 20, 30 and 60 min, respectively. Biodistribution pattern was observed. Regions of interest were manually delineated. Radiation dosimetry of all target organs were calculated by Olinda/EXM software. Results The radioactive uptake dissipated gradually in liver whereas it was relatively stable in tumor lesions. The average SUVmax of tumor lesions reached the maximum value (13.87±2.55) at 20 min after injection. The target-to-background ratio increased with time, reaching the maximum value (10.09 ±8.17) at 30 min after injection. The average effective dose in total body was (0.020 ±0.002) mSv/MBq and organ with the highest effective dose was bladder wall at (0.146 ±0.035) mSv/MBq. Conclusions The effective dose in total body of 68Ga-FAPI-04 was similar to that of 18F-FDG. 68Ga-FAPI-04 is expected to be a PET/CT radiotracer for hepatobiliary tumors in consideration of rapid tumor uptake, low accumulation of liver background, and no influence of blood sugar levels. |
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