| 李敏杰,黄平平.基于体膜开窗定位的保乳术后大分割与常规分割的不良反应对比[J].中华放射医学与防护杂志,2021,41(4):271-275 |
| 基于体膜开窗定位的保乳术后大分割与常规分割的不良反应对比 |
| Comparison of adverse reactions between hypofractionated radiotherapy and conventional radiotherapy after breast conserving surgery based on body membrane fenestration |
| 投稿时间：2020-10-23 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.006 |
| 中文关键词: 分割放疗 常规分割 乳腺癌 保乳术 体膜 |
| 英文关键词:Hypofractionated radiotherapy Conventional radiotherapy Breast cancer Breast conserving surgery Body membrane |
| 基金项目:安徽省自然科学基金面上项目（2008085MA24） |
|
| 摘要点击次数: 1931 |
| 全文下载次数: 925 |
| 中文摘要: |
| 目的 分析基于体膜开窗定位方式的乳腺癌保乳术后大分割放疗和常规分割放疗患者的不良反应、美容效果，对改良定位方式进行探讨。方法 前瞻性对2019年1月至2020年4月收治的75例乳腺癌保乳术后患者，采用随机数字表法分为两组：大分割组，38例，42.4 Gy/16次，2.65 Gy/次；常规组，37例，50 Gy/25次，2.0 Gy/次。均采用热塑体膜定位，并沿患侧乳腺根部将乳房上方体膜剪去。观察两组的不良反应、美容效果及随访生存情况。结果 随访期间，两组患者8个月内无复发病例，局部控制率100%，生存率100%。两组患者急性皮肤反应总发生率为大分割组36.84%（14/38）和常规组67.57%（25/37），差异有统计学意义（χ2=7.09，P<0.05）；美容效果优良率为大分割组89.47%（34/38）和常规组78.38%（29/37），但差异无统计学意义（P>0.05）；白细胞减少、血小板减少及晚期皮肤反应差异无统计学意义（P>0.05）。结论 基于体膜开窗定位方式的乳腺癌保乳术后大分割放疗方案具有可行性，可明显减轻急性放射性皮肤反应，且并未增加放疗不良反应。但长期效果仍需长期随访研究来证实。 |
| 英文摘要: |
| Objective To analyze the adverse reactions, cosmetic effects and the improvement in positioning of breast cancer patients who received breast-conserving operation followed by hypofractionated radiotherapy and conventional radiotherapy based on the positioning of body membrane method with windowing method. Methods From January 2019 to April 2020, 75 patients with breast cancer were randomly divided into two groups:hypofractionated radiotherapy (38 cases) administered with 42.4 Gy/16 fractions (2.65 Gy/fraction), and conventional group (37 cases) with 50 Gy/25 fractions (2.0 Gy/fraction). All of them were located by thermoplastic film, and the upper parts of the thermoplastic film were cut along the root of the breast. The adverse reactions, cosmetic effect and follow-up survival of the two groups were observed. Results During the follow-up period, there was no recurrence in the two groups within 8 months. The local control rate and the survival rate of all the patients were both 100%. The total incidence of acute skin reaction in the two groups was 36.84% (14/38) in the hypofractionated group and 67.57% (25/37) in the conventional group (χ2=7.09, P<0.05). The excellent and good rate of cosmetic effect was 89.47% (34/38) in the hypofractionated group and 78.38% (29/37) in the conventional group, but the difference was not statistically significant (P>0.05). There were not statistically differences in the late skin reaction, leucopenia and thrombocytopenia between the two groups (P>0.05). Conclusions Breast-conserving surgery followed by hypofractionated radiotherapy with the positioning of body membrane windowing localization method is feasible and safe. Also, it can significantly reduce the acute radiation skin reactions. But the long-term effects still need to be confirmed by long-term follow-up. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |