| 陶寅,张增鹏,刘红冬,徐榭,裴曦,陈志.基于不同相对生物效应模型评估质子放疗生物剂量[J].中华放射医学与防护杂志,2021,41(4):265-270 |
| 基于不同相对生物效应模型评估质子放疗生物剂量 |
| Assessment of biological dose of proton radiotherapy based on different relative biological effect models |
| 投稿时间：2020-11-06 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.04.005 |
| 中文关键词: 蒙特卡罗 质子 生物剂量 平均传能线密度 |
| 英文关键词:Monte Carlo Proton Biological dose Linear energy transfer |
| 基金项目:安徽省自然科学基金面上项目（2008085MA24） |
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| 摘要点击次数: 1965 |
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| 中文摘要: |
| 目的 评估两种相对生物效应模型计算的生物剂量，并与传统临床质子放疗生物剂量相比较。方法 使用粒子模拟工具（TOPAS）分别在水箱和两例患者模体（脑部和前列腺）计算物理剂量、剂量平均LET （dose averaged linear energy transfer，LETd）和径迹平均LET （track averaged linear energy transfer，LETt）的全空间分布，并根据两种不同机制相对生物效应模型计算生物剂量DoseLETd和DoseLETt，计算传统临床质子生物剂量（Dose1.1）时取相对生物效应为1.1。在水箱中对比3种生物剂量的差异，在患者模体中为了量化3种方法的差异，根据物理剂量大小选取3个点（D1、D2、D3）的生物剂量相比较。结果 水箱中DoseLETd和DoseLETt随水深度变化表现趋势一致，在质子束射程末端均高于Dose1.1。在患者模体中，DoseLETd和DoseLETt最大差异为10.08 cGy，相对差异<5%。DoseLETd和DoseLETt与Dose1.1相比，在脑部肿瘤靶区最大差异分别为71.97和61.91 cGy，相对差异<25%；在前列腺肿瘤靶区内最大差异分别为25.95和19.96 cGy，相对差异<12%；但在靶区外差异很小，脑部和前列腺肿瘤靶区外最大差异分别为5.99和9.92 cGy，相对差异<5%。结论 基于LETd和LETt的两种相对生物效应模型计算的生物剂量在水箱和患者模体差异很小，但与传统临床质子放疗生物剂量相比时在高剂量区有很大的差异。 |
| 英文摘要: |
| Objective To assess proton biological dose with using two kinds of relative biological effect models and to compare them with traditional clinical proton biological dose (Dose1.1). Methods Based on Particle simulation tools(TOPAS), physical dose, LETd and LETt were calculated in water phantom and two anthropomorphic phantoms (brain and prostate tumors) respectively. Then DoseLETd and DoseLETt were calculated according to different relative biological effect models, an RBE was 1.1 in traditional clinical proton biological dose calculation. Three kinds of biological doses were compared in the water phantom. To quantify the differences between three method in anthropomorphic phantoms, three points (D1, D2, D3) were selected according to the physical dose to compare the biological dose. Results DoseLETd and DoseLETt in water phantom showed the same trend with water depth and both of them were higher than Dose1.1 at the end of proton beam range. The maximal difference between DoseLETd and DoseLETt in the anthropomorphic phantoms was 10.08 cGy, where the relative difference was less than 5%. When DoseLETd and DoseLETt were compared with Dose1.1, the maximal differences in brain tumor target were 71.97 cGy and 61.91 cGy respectively, where the relative differences were less than 25%. The maximal differences in prostate tumor target were 25.95 and 19.96 cGy respectively, where the relative differences were less than 12%. However, the differences outside the target were very small, where the maximal differences in brain and prostate tumors were 5.99 cGy and 9.92 cGy respectively, and the relative differences were less than 5%. Conclusions Biological doses calculated by two method are of little difference in both water and anthropomorphic phantoms, however, large differences were observed when they were compared with the traditional clinical proton biological dose especially in the high dose area. |
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