| 衣峻萱,王蕊,魏新锋,等.RNA的m6A修饰在恶性肿瘤及其放疗中作用机制的研究进展[J].中华放射医学与防护杂志,2021,41(3):234-240.Yi Junxuan,Wang Rui,Wei Xinfeng,et al.Research progress of RNA m6A modification in malignant tumor and its mechanism of radiotherapy[J].Chin J Radiol Med Prot,2021,41(3):234-240 |
| RNA的m6A修饰在恶性肿瘤及其放疗中作用机制的研究进展 |
| Research progress of RNA m6A modification in malignant tumor and its mechanism of radiotherapy |
| 投稿时间：2020-11-30 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.03.014 |
| 中文关键词: m6A甲基化修饰 甲基转移酶 去甲基酶 甲基化识别酶 放射治疗 |
| 英文关键词:N6-methyladenosine modification Writers Erasers Readers Radiation Therapy |
| 基金项目:国家自然科学基金面上项目（81872550， 81573085） |
|
| 摘要点击次数: 3391 |
| 全文下载次数: 1776 |
| 中文摘要: |
| N6-甲基腺苷（N6-methyladenosine，m6A）是哺乳动物中最丰富的RNA碱基修饰，尤其是在真核信使RNA（mRNA）中。m6A修饰可调节RNA的剪接，易位和稳定性，进而影响蛋白质的合成。m6A修饰被RNA甲基转移酶（writers）催化；通过去甲基酶（erasers）还原；还可以被甲基化识别酶（readers）识别。基因的m6A水平异常变化与肿瘤的发生和发展密切相关，即包括增殖、生长、侵袭和转移等。在肿瘤的放射治疗过程中，m6A修饰通过影响DNA损伤、肿瘤干细胞生成、以及肿瘤细胞辐射敏感性等，进而影响放疗疗效。本文就RNA的m6A修饰的表观遗传调控在恶性肿瘤中的作用以及在肿瘤放疗中作用机制的研究进展进行了综述，旨在为临床肿瘤分子靶向疗法和放射增敏剂的研发提供新的思路。 |
| 英文摘要: |
| N6-methyladenosine (m6A) is the most abundant RNA base modification in mammals, especially in eukaryotic messenger RNA (mRNA). N6-methyladenosine modification can regulate RNA splicing, translocation, stability and ultimately affect protein synthesis. m6A modification is catalyzed by RNA writers, reduced by erasers and also be recognized by readers. Abnormal changes ofm6A levels are closely related to tumor occurrence and development, including proliferation, growth, invasion and metastasis. In the process of tumor radiotherapy, m6A modification affects the efficacy of radiotherapy by affecting DNA damage, tumor stem cell generation and tumor cell radiation sensitivity. This article reviews the role of m6A-modified epigenetic regulation in malignant tumors and the research progress of its mechanism in tumor radiotherapy, in order to provide new ideas for the development of clinical tumor molecular targeted therapies and radiosensitizers. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |