| 史金明,刘文扬,金晶.胃食管结合部腺癌与中远端胃癌术前同步放化疗研究进展[J].中华放射医学与防护杂志,2020,40(10):802-806 |
| 胃食管结合部腺癌与中远端胃癌术前同步放化疗研究进展 |
| Progress of preoperative chemoradiotherapy in adenocarcinoma of esophagogastric junctionand mid-distal gastric cancer |
| 投稿时间：2020-06-01 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.10.013 |
| 中文关键词: 胃食管结合部腺癌 中远端胃癌 术前同步放化疗 |
| 英文关键词:Adenocarcinoma of esophagogastric junction Mid-distal gastric cancer Preoperative chemoradiotherapy |
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| 摘要点击次数: 1628 |
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| 中文摘要: |
| 胃癌在我国发病率高居第二位，初诊胃癌患者分期晚，单纯手术的根治性切除率低且术后复发率高，整体预后较差，同步放化疗作为局部治疗方式在胃癌中逐渐体现出重要价值。近年来，虽然中远端胃癌患者仍然是主要患病人群，但随着生活习惯的改变，胃食管结合部腺癌患者发病数量逐渐上升，其预后相对中远端胃癌差。已有大型Ⅲ期研究证实了术前同步放化疗可以提高胃食管结合部腺癌的降期率及局部控制率。但是中远端胃癌仍缺乏Ⅲ期研究证据，尚需更多临床研究来探索同步放化疗的价值。本文将分别对胃食管结合部腺癌和中远端胃癌术前同步放化疗的研究现况进行阐述。 |
| 英文摘要: |
| In China, gastric cancer ranks in the second place in morbidity. Patients were mostly diagnosed as an advanced stage at the first time. Radical resection rate was low and the recurrence rate remained high by surgery alone, which resulted in a poor prognosis. Preoperative chemoradiotherapy served as a local therapy method played an important role in gastric cancer gradually. In recent years, although most patients' tumor are located at the mid-distal gastric cancer, due to the changes of living habits, the number of patients with gastroesophageal junction adenocarcinoma has gradually increased, and their prognosis are relatively poorer compared with the mid-distal gastric cancer.Large-scale phase Ⅲ studies have confirmed that preoperative radiotherapy and chemotherapy can improve the rate of downstaging and local control in adenocarcinoma of the gastroesophageal junction. However, mid-distal gastric cancer still lacks phase Ⅲ evidence and more clinical studies are needed to explore the value of preoperative chemoradiotherapy. This review summarizes the progress of preoperative chemoradiotherapy in adenocarcinoma of esophagogastric junction and mid-distal gastric cancer separately. |
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