| 陈唯唯,王文玲,王刚,李小凯,李国栋,董洪敏.X射线修复交叉互补基因1多态性与直肠癌新辅助放化疗疗效的前瞻性队列研究[J].中华放射医学与防护杂志,2020,40(10):740-745 |
| X射线修复交叉互补基因1多态性与直肠癌新辅助放化疗疗效的前瞻性队列研究 |
| Correlation analysis of XRCC1 gene rs25487 polymorphism and effect of concurrent neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a prospective cohort study |
| 投稿时间：2020-05-21 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.10.002 |
| 中文关键词: 直肠癌 新辅助放化疗 X射线交叉互补基因1 基因多态性 交互作用 |
| 英文关键词:Rectal cancer Neoadjuvant chemoradiotherapy X-ray cross-complementary gene 1 Gene polymorphism Interaction |
| 基金项目:贵州省教育厅青年科技人才成长项目（黔教合KY字[2016]151） |
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| 中文摘要: |
| 目的 探讨局部进展期直肠癌X射线修复交叉互补基因1（XRCC1 rs25487）多态性与新辅助放化疗相关性。方法 使用前瞻性队列研究，纳入于2018年8月至2019年7月在贵州省肿瘤医院腹部肿瘤科就诊的55例局部进展期直肠癌患者，对患者进行新辅助同步放化疗，于同步放化疗前采血并进行DNA测序确定XRCC1 rs25487基因型。采用调整混杂因素的logistic回归分析研究肿瘤新辅助放化疗后T分期、N分期降期情况与患者XRCC1 rs25487基因多态性的关系并分层分析探究各基因型与中性粒细胞淋巴细胞比值（NLR）等临床特征的交互作用。结果 各基因型频率均符合Hardy-Weinberg平衡。调整混杂因素以后，相较于AA基因型患者，GG型患者新辅助放化疗后T降期率减低（OR=0.1，P<0.05）。而GA型患者新辅助放化疗后无论是T降期率还是N降期率，与AA基因型患者差异均无统计学意义（P>0.05）。并且AA/GA基因型与NLR存在交互作用而影响放疗后T降期率。结论 XRCC1 rs25487基因多态性与局部进展期直肠癌患者新辅助放化疗的疗效相关，且与NLR值有交互作用，可能成为新辅助放化疗疗效的预测因子。 |
| 英文摘要: |
| Objective To investigate the correlation between the X-ray cross-complementary gene 1 (XRCC1) rs25487 gene polymorphism and the effect of neoadjuvant chemoradiotherapy for locally advanced rectal cancer (LARC ). Methods This research was a prospective cohort study consisting of 55 patients with LARC who were treated in the Affiliated Hospital, Guizhou Cancer Hospital of Guizhou Medical University from August 2018 to July 2019. The XRCC1 rs25487 genotype was detected, followed by neoadjuvant chemoradiotherapy. The logistic regression with adjusted confounding factors was used to analyze the relationship between down-staging of T-stage and N-stage and XRCC1 rs25487 gene polymorphism. The stratified analysis was used to explore interactions of neutrophil lymphocyte ratio (NLR) based on logistic regression. Results The frequencies of all genotypes were in accordance with Hardy-Weinberg equilibrium. After adjusting confounding factors, compared to patients with AA genotype, patients with GG genotype had lower rate of down-staging of T-stage after neoadjuvant radiotherapy (OR=0.1, P<0.05 ). However, there was no statistically significant difference between GA and AA genotypes (P>0.05 ). There was interactions between AA/GA genotypes and NLR, which affected the down-staging of T-stage after radiotherapy. Conclusions XRCC1 rs25487 gene polymorphism is associated with the efficacy of neoadjuvant radiotherapy and concurrent system chemotherapy in patients with LARC, which may be used as a predictor of the efficacy of neoadjuvant intensive therapy. |
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