| 唐颖,苏世标,靳雅丽,林海辉,温翠菊,谈伟君.天然高本底地区人群白介素水平及转化生长因子β1水平调查[J].中华放射医学与防护杂志,2020,40(5):349-354 |
| 天然高本底地区人群白介素水平及转化生长因子β1水平调查 |
| Investigation on the levels of interleukins and TGF-β1 in the population in natural high background area |
| 投稿时间：2019-10-28 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.05.004 |
| 中文关键词: 高本底辐射 白介素 适应性反应 |
| 英文关键词:High background radiation Interleukin Adaptive response |
| 基金项目:国家自然科学基金青年科学基金项目（81602804） |
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| 摘要点击次数: 1908 |
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| 中文摘要: |
| 目的 调查长期低剂量电离辐射对天然高本底地区（high background radiation areas，HBRA）人群白介素（IL）和转化生长因子β1（TGF-β1）水平的影响。方法 采用完全随机方法从高本底地区阳江塘口镇和对照地区恩平市横坡镇分别选取45~65岁健康男性41名和44名，外周静脉血离心分层后取上层血浆，采用酶联免疫吸附实验（ELISA）检测IL-2、sIL-2R、IL-4、IL-5、TGF-β1的血浆含量。对两地区居民血浆白介素进行比较，并通过协方差分析观察地区、年龄、吸烟、饮酒、收入等对上述指标的影响。结果 HBRA健康居民除IL-2的浓度略高于对照地区外，其余指标均低于对照地区居民，其中IL-5（t=7.124，P<0.001）、TGF-β1（t=4.900，P<0.001）的统计结果在两地区之间差异有统计学意义，协方差分析结果提示吸烟对IL-2水平影响差异有统计学意义（F=5.283，P<0.05）。结论 受长期低剂量电离辐射影响，阳江天然高本底地区居民血浆白介素各种类呈现不同的水平改变，免疫平衡偏向Th1型细胞因子，免疫功能略强于对照地区，提示长期慢性低剂量电离辐射可能诱导机体免疫功能发生适应性改变，其机制有待进一步研究。 |
| 英文摘要: |
| Objective To investigate the effect of long-term low dose ionizing radiation on the levels of interleukin (IL) and TGF-β1 in the population in high background radiation area(HBRA). Methods Appropriate amount of peripheral blood was drawn from 41 and 44 healthy men aged 45-65 years who were randomly selected from Tangkou town of Yangjiang city (HBRA) and Hengpo town of Enping city (control area, CA), respectively. After centrifugation and stratification, the upper plasma of blood was separated to determine IL-2, sIL-2R, IL-4, IL-5 and TGF-β1 by using ELISA. The difference of plasma IL of the residents in those two regions was analyzed. The influence of region, age, smoking, drinking and income on the indexes of ILs and TGF-β1 was evaluated by Covariance analysis. Results The concentration of IL-2 at HBRA area was slightly higher than those in the control area, but the other indexes were lower than those in CA residents. The differences of IL-5 (t=7.124, P<0.001) and TGF-β1 (t=4.900, P<0.001) between two areas were significant statistically. Covariance analysis showed that smoking had a significant effect on IL-2 level (F=5.283,P<0.05). Conclusions Under the influence of long-term low-dose ionizing radiation, all kinds of plasma interleukin levels of residents in HBRA were different with that in CA. The immune balance was biased towards Th1 type cytokines, and the immune function in HBRA was slightly stronger than that in CA, suggesting that long-term chronic low-dose ionizing radiation may induce adaptive changes in the immune function, which needs further study. |
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