| 高晶,胡集祎,杨婧,等.26例脑膜瘤的质子放射治疗初步临床结果[J].中华放射医学与防护杂志,2020,40(4):302-307.Gao Jing,Hu Jiyi,Yang Jing,et al.Primary results of proton radiotherapy for 26 meningioma patients[J].Chin J Radiol Med Prot,2020,40(4):302-307 |
| 26例脑膜瘤的质子放射治疗初步临床结果 |
| Primary results of proton radiotherapy for 26 meningioma patients |
| 投稿时间：2019-06-07 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.04.010 |
| 中文关键词: 质子治疗 脑膜瘤 不良反应 疗效 |
| 英文关键词:Proton therapy Meningioma Toxicities Efficacy |
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| 中文摘要: |
| 目的 考察质子射线放射治疗世界卫生组织（WHO）Ⅰ/Ⅱ级脑膜瘤的初步疗效及不良反应。方法 回顾性分析2015年5月至2018年10月上海市质子重离子医院治疗脑膜瘤患者26例，其中18例为颅底脑膜瘤。患者的中位年龄为42岁（范围15~79岁）。病理诊断为WHOⅠ级脑膜瘤的患者8例，病理诊断为WHO Ⅱ级的脑膜瘤患者9例，影像学诊断患者9例。7例患者为术后放疗（Simpson Ⅰ~Ⅲ级切除2例，Simpson Ⅳ~Ⅴ级切除5例），10例患者为术后复发后放疗。结果 中位随访时间为22.2个月，所有患者均完成了既定的质子射线放射治疗，中位等效剂量为54 GyE（范围50.4~60 GyE）， 单次剂量为1.8~2.0 GyE。治疗后70%患者症状部分缓解，2年无进展生存率（PFS）和总生存率（OS）均为100%。治疗期间急性放射反应轻微，仅出现1级脱发（n=22）和黏膜反应（n=2），无2级及以上急性反应，目前尚未观察到晚期不良反应。结论 质子治疗颅内及颅底脑膜瘤安全有效，长期疗效及不良反应需进一步随访。 |
| 英文摘要: |
| Objective To investigate the safety and efficacy of proton beam radiation therapy (PBRT) in patients with World Health Organization (WHO) GradeⅠ/Ⅱ meningioma. Methods Twenty-six patients with intracranial (n=8, 30.8%) or skull-base (n=18, 69.2%) meningioma treated with PBRT from May 2015 to October 2018 were analyzed retrospectively. The median age of the cohort was 42 years (range 15-79 years). Eight patients had WHO Grade Ⅰ meningioma, and 9 had WHO Grade Ⅱ meningioma, respectively. Nine patients had clinical (radiological) diagnosis without histology. Seven patients received post-surgical PBRT (2 patients underwent Simpson Ⅰ-Ⅲ resection,5 patients underwent Simpson Ⅳ-Ⅴ resection); 10 patients were irradiated for local recurrence after initial surgical resection. Results All patients completed planned PBRT without break, and the median dose was 54 Gray-Equivalent (GyE) (range 50.4-60 GyE, 1.8-2 GyE/daily fraction). With a median follow-up of 22.2 (range 1.6-36.4) months, the 2-year overall survival and progression-free survival rates were both 100%. Grade Ⅰ skin erythema and alopecia were observed in 22 patients and Grade Ⅰ mucositis was observed in 2 patients. No acute of late toxicities of Grade 2 or above was observed. Conclusions PBRT appeared to be a favorable treatment option for intracranial and skull base meningioma. Treatment-induced adverse effects and early response to PBRT were both highly acceptable. Longer follow-up is needed to evaluate the long-term outcome in terms of disease control, survival, as well as potential late effects. |
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