| 朱瑶瑶,杨双燕,杨文艳,林清认,邵凯南,徐清华,刘辉,许亚萍.30例T2N0M0期非小细胞肺癌立体定向放射治疗临床疗效分析[J].中华放射医学与防护杂志,2019,39(12):904-909 |
| 30例T2N0M0期非小细胞肺癌立体定向放射治疗临床疗效分析 |
| Clinical outcomes of stereotactic body radiation therapy for T2N0M0 non-small cell lung cancer |
| 投稿时间：2019-07-24 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.12.005 |
| 中文关键词: 立体定向放射治疗 非小细胞肺癌 总生存 无进展生存 肿瘤特异性生存 |
| 英文关键词:Stereotactic body radiation therapy Non-small cell lung cancer Overall survival Progression-free survival Cause-specific survival |
| 基金项目:山东省重点研发计划项目（2018GSF118048） |
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| 中文摘要: |
| 目的 探讨利用体部立体定向放射治疗（SBRT）技术治疗T2N0M0期非小细胞肺癌（NSCLC）的临床疗效及不良反应。方法 回顾性分析接受SBRT治疗的30例不适合手术T2N0M0期NSCLC患者的临床资料，探讨其总生存率、无进展生存率、肿瘤特异性生存率和不良反应。结果 中位随访时间18.4个月。1、2、3年的总生存率分别为92.2%、92.2%和80.6%，肿瘤特异性生存率分别为95.7%、95.7%和83.7%，无进展生存率分别为70.2%、54.1%和40.6%，局部控制率分别为100%、94.4%和94.4%，区域控制率分别为84.2%、72.1%和54.1%，远处控制率分别为84.6%、72.4%和64.3%。20例患者出现1级放疗相关不良反应；5例患者出现≥2级的放射性肺炎；1例患者出现4级放射性肺炎。结论 SBRT治疗对不适合手术的T2N0M0期NSCLC患者有较好的疗效，不良反应可耐受。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy and adverse effects of stereotactic body radiotherapy (SBRT) in the treatment of T2N0M0 non-small cell lung cancer (NSCLC) patients. Methods By retrospectively analyzing the clinical data of 30 inoperable patients with stage T2N0M0 NSCLC treated by SBRT, the overall survival, progression-free survival, cancer-specific survival and adverse effects were determined. Results The median follow-up was 18.4 months. The 1-, 2-, and 3-year overall survival rates were 92.2%, 92.2% and 80.6%, respectively. The corresponding cause-specific survivals were 95.7%, 95.7% and 83.7%. The progression-free survivals were 70.2%, 54.1% and 40.6%. The local control rates were 100%, 94.4%, and 94.4%. The regional controls were 84.2%, 72.1%, and 54.1%; and distant controls were 84.6%, 72.4% and 64.3%, respectively. Twenty patients (66.7%) developed symptoms of grade 1 radiation-related toxicities:dyspnea, chest pain, fatigue, cough, esophagitis, or pneumonia. Among these, 5 patients suffered grade ≥ 2 radiation pneumonitis, and one patient experienced grade 4 radiation pneumonitis. Conclusions SBRT was efficient and safe for patients with inoperable T2N0M0 NSCLC, imposing tolerable toxicities. |
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