| 顾莹,邢鹏飞,蔡尚,等.磁共振模拟定位及磁共振诊断影像与定位CT融合的精准性比较[J].中华放射医学与防护杂志,2019,39(11):827-832.Gu Ying,Xing Penfei,Cai Shang,et al.Comparison in precision of image registration between MRI simulation and diagnostic MRI with CT simulation[J].Chin J Radiol Med Prot,2019,39(11):827-832 |
| 磁共振模拟定位及磁共振诊断影像与定位CT融合的精准性比较 |
| Comparison in precision of image registration between MRI simulation and diagnostic MRI with CT simulation |
| 投稿时间：2019-03-26 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.11.005 |
| 中文关键词: MRI模拟定位 影像融合 刚性匹配 诊断MRI 精准性 |
| 英文关键词:MRI simulation Image fusion Rigid registration MRI diagnosis Precision |
| 基金项目:江苏省重点研发计划专项（BE2018657） |
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| 中文摘要: |
| 目的 与磁共振成像（MRI）诊断影像（MRIdiag）相比较，评估MRI模拟定位影像（MRIsim）与模拟CT融合的精准性，为MRIsim的进一步应用提供参考。方法 选择行MRIsim同时又有MRIdiag的患者24例，其中脑胶质瘤、鼻咽癌和前列腺癌各8例。将每位患者的MRIsim、MRIdiag影像分别与模拟CT融合，在3种图像上分别勾画危及器官（OAR），在CT与MRIsim融合影像（F_CTMsim）、CT与MRIdiag融合影像（F_CTMdiag）上分别勾画靶区。评估基于MRIsim、MRIdiag与CT之间OAR的一致性指数（CI）、形似指数（DSC）、图像相似性指数（S）。基于F_CTMsim的靶区和CT的OAR设计IMRT计划，评估靶区和OAR的剂量学差异。结果 除了鼻咽癌患者的全脑和前列腺癌患者的盆骨外，其余OAR基于3种图像的体积值无明显差异（P>0.05）；MRIsim的所有OAR与CT比较的CI和DSC值均高于MRIdiag，其中50%的OAR差异有统计学意义（t=2.58~5.47，P<0.05）。MRIsim、MRIdiag与CT比较，S值分别为0.89、0.83（t=5.77，P<0.05），相对于MRIdiag，MRIsim改善了S值10%（2%~56%）。OAR和靶区剂量学差异无统计学意义（P>0.05）。结论 相对于MRIdiag，将MRIsim引入放疗与模拟CT融合可以明显改善图像匹配的精准性。但两者基于刚性匹配肿瘤区域结合手动调整方法所勾画的靶区之间没有剂量学差异。 |
| 英文摘要: |
| Objective To evaluate the precision of image registration between MRI simulation (MRIsim) and CT simulation compared to diagnostic MRI(MRIdiag) and to provide information for further application of MRIsim. Methods A total of 24 patients who underwent both MRIsim and MRIdiag were enrolled, including 8 patients with gliomas, 8 with nasopharyngeal carcinomas and 8 with prostate cancers. MRIsim and MRIdiag images of each patient were fused with CT. The OARs were delineated on three modalities of images and targets were delineated on fusion image of MRIsim with CT (F_CTMsim) and fusion image of MRIdiag with CT (F_CTMdiag) respectively. The concordance index (CI), Dice's similarity coefficient (DSC) between the OARs and image similarity index (S) based on images from MRIsim, MRIdiag and CT were evaluated. IMRT plans were designed based targets on F_CTMsim and OARs on CT images, and differences in dosimetry of targets and OARs were evaluated subsequently. Results Volumes of most OAR from three modalities of images showed no statistically significant difference(P>0.05). All the CI and DSC between the OARs derived from MRIsim and CT were higher than those corresponding values from MRIdiag, and a statistically significant difference was achieved in 50% of these OARs (t=2.58-5.47, P<0.05). The S values of MRIsim and MRIdiag compared with CT were 0.89 and 0.83 respectively (t=5.77, P<0.05). MRIsim improved the S value by 10% (2%-56%) compared with MRIdiag. No further differences in dosimetry were found on all OARs and all targets(P>0.05). Conclusions The precision of image registration can be significantly improved by introducing MRIsim into radiotherapy planning design compared with MRIdiag. However, no significant differences in dosimetry were found on targets produced by rigid registration and manual adjustment method. |
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