| 刘忠山,李云峰,任晓俊,林霞,王红勇,于多,张宝玉,王铁君,郭杰.近距离治疗的临床放射生物学[J].中华放射医学与防护杂志,2019,39(8):590-593 |
| 近距离治疗的临床放射生物学 |
| Clinical radiobiology of brachytherapy |
| 投稿时间：2019-04-02 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.08.005 |
| 中文关键词: 近距离治疗 临床治疗 放射生物学 |
| 英文关键词:Brachytherapy Clinical treatment Radiobiology |
| 基金项目:国家重点研发计划项目（2017YFC0108602）；吉林省卫生厅卫生科研计划项目（2015Z009） |
|
| 摘要点击次数: 2377 |
| 全文下载次数: 1052 |
| 中文摘要: |
| 近距离治疗是将放射性同位素植入或置于肿瘤周边的一种技术。中心高剂量及随着距离的增加剂量迅速衰减是其最大的特点。近距离治疗主要包括低剂量率、高剂量率和脉冲剂量率3种。近距离治疗的最大优势是保证肿瘤组织充足剂量的基础上降低周围正常组织的放射性损伤。临床近距离治疗技术的进步与其放射生物学特点联系紧密。临床近距离治疗放射生物学的基本概念主要包括剂量率效应、放射性损伤的修复、再氧合、细胞周期的再分布及再群体化。探索近距离治疗放射生物学与临床近距离治疗效果的关系，利用近距离治疗的放射生物学特点，指导临床上近距离治疗的具体应用需要大量转化医学的工作。最终的目的是增加肿瘤局部控制率、降低不良反应及提高患者最终的生存期。 |
| 英文摘要: |
| Brachythrapy is a technique to implant radioactive isotype into or near tumors. The obvious properties of brachytherapy are a very high dose distribution of center, and rapid dose attenuation with the increasing of distance. Brachytherapy generally includes three major categories:low dose rate, high dose rate and pulse dose rate. The most significant clinical value of brachytherapy is that it could create dose distribution to tumor tissues, but decreased radiation injury of normal tissues close to tumor. The development of the clinical brachytherapy technique is always involved in the radiobiological characteristics. The basic concepts involving clinical brachytherapy radiobiology mainly includes:dose-rate effect, repair of radiation injury, re-oxygenation, cell cycle redistribution and repopulation. An amount of translational medical approach is needed to guide the application of clinical brachytherapy by exploring the interaction between brachytherapy radiobiology and clinical brachytherapy effect, as well as taking advantage of brachytherapy radiobiological characteristics. The ultimate goal is to improve tumor local control rate, reduce the occurrence of adverse reactions, and improve patients' overall survival. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|