| 王巍伟,陈帜,Kambiz Shahnazi,黄志杰,盛尹祥子.探测临床质子碳离子布拉格峰声信号的初步研究[J].中华放射医学与防护杂志,2019,39(6):460-464 |
| 探测临床质子碳离子布拉格峰声信号的初步研究 |
| Preliminary investigation of detecting acoustic signal created by clinical proton and carbon ion Bragg-peak |
| 投稿时间：2019-02-27 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.06.011 |
| 中文关键词: 质子 碳离子 射程验证 离子声信号 |
| 英文关键词:Proton Carbon ion Range verification Ionaccoustic |
| 基金项目:上海市卫生计生委青年基金项目（20174Y0134）；上海市青年科技英才杨帆计划（16YF1410700） |
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| 中文摘要: |
| 目的 验证一种高灵敏度宽频声学探测器测量临床质子碳离子布拉格峰声信号可行性。方法 将该声学探测器紧贴在圆柱状水箱后方。水箱水等效深度使用寻峰设备（Peakfinder，PTW，德国西门子）经高能质子测定。通过固定总离子数，分别改变离子流强和布拉格峰到探测器前表面距离来研究布拉格峰声信号强度与探测器到布拉格峰距离和流强关系；改变束流与探测器侧向位置来研究测量布拉格峰横向半高宽可行性。结果 束流开始或束流结束产生的声脉冲幅度可间接表示声信号强度。质子布拉格峰声信号强度与探测器到布拉格峰深度距离呈反比，与流强呈正比，125.43 MeV质子布拉格峰横向半高宽与治疗计划系统模拟值最大偏差11.7%（取束流开始或结束测量数据中最大值）。碳离子呈相似规律，但178.89 MeV/u碳离子布拉格峰横向半高宽比治疗计划系统模拟值偏大45.6%（束流结束测量值），探测器到布拉格峰深度距离可显著增加至67.7 mm。结论 该声学探测器可有效探测质子碳离子布拉格峰声信号，但需进一步降低噪声影响。 |
| 英文摘要: |
| Objective To investigate a system for the detection of the acoustic signal created by clinical proton and carbon ion Bragg-peaks (BPs). Methods An acoustic detector was attached to water phantoms downstream of the beam. The water-equivalent depth of this phantom was measured by a peakfinder (PTW, Siemens, Germany) using high energy proton beams. By maintaining the same particle number, either the BP to detector distance (BTD) or beam intensity was changed to investigate their relationships with the magnitude of acoustic signal. By moving the beam spot in lateral directions, the full width at half maximums (FWHMs) of BPs was measured and compared. Results The detected acoustic signal created by beam on or beam off could represent the magnitude of signal, which was proven by a statistical analysis. The magnitude of acoustic signals created by proton BPs were inversely proportional to BTD, but proportional to intensities. The measured FWHM of 125.43 MeV proton BP was 11.7% larger than data from the treatment planning system (TPS). Carbon ion showed similar result whereas the measured FWHM of 178.89 MeV/u carbon ion BP was 45.6% larger than the data from TPS. The BTDs could be more than 67.7 mm while maintaining enough magnitude of acoustic signal. Conclusions This acoustic detection system can detect the acoustic waves from clinical proton and carbon ion BPs. However, further investigation is ongoing to decrease the noise. |
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