| 冉永红,高继宁,卢丙慧,贺莹娟,粟永萍,郝玉徽.放创复合伤创面难愈机制及治疗的研究进展[J].中华放射医学与防护杂志,2018,38(11):874-880 |
| 放创复合伤创面难愈机制及治疗的研究进展 |
| Research progresses in the mechanism and treatment of the impaired wound healing of combined radiation-trauma injury |
| 投稿时间：2018-05-24 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.11.015 |
| 中文关键词: 放创复合伤 创面难愈 机制 治疗 |
| 英文关键词:Combined radiation trauma Impaired wound healing Mechanism Therapy |
| 基金项目:国家自然科学基金（AWS13J002，AWS14J002，81472913，81741112）；重庆市基础与前沿研究计划项目（cstc2016jcyjA0408） |
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| 中文摘要: |
| 放创复合伤主要见于肿瘤放疗以及核辐射损伤等合并创伤的患者，其突出的问题是创面愈合延迟或经久不愈；放创复合伤伤口难愈的机制复杂，目前的临床治疗手段也有限。本文就放创复合伤创面难愈的机制和治疗进行综述，主要包括细胞衰竭、基质细胞功能障碍、异常胶原沉积、微血管损伤等创面难愈机制以及干细胞治疗、抗氧化治疗、转化生长因子-1（transforming growth factor-β，TGF-β1）的调节、植入生物材料等针对难愈机制的靶向治疗手段，旨在为放创复合伤创面难愈机制及治疗的进一步研究提供参考。 |
| 英文摘要: |
| Combined radiation-trauma injury is mainly observed in radiation treatment of cancer and radiation injury with traumatic patients. The prominent problem of combined radiation-trauma injury is delayed or prolonged wound healing. The mechanism of the impaired wound healing is complicated, and the current effective treatment method are limited. This paper reviews the mechanism and treatment of this impaired wound healing, including the cellular depletion, stromal cell dysfunction, aberrant collagen deposition, microvascular damage, as well as the targeted therapies for the impaired wound healing such as stem cell repletion, antioxidant therapy, transforming growth factor beta-1 (TGF-β1) modulation, and implantable biomaterials. This paper is designed to provide a reference for further deep research on the mechanism and treatment of radiation-trauma injury. |
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