| 高飘阳,杜利清,刘强.白藜芦醇的放射防护作用及其机制研究进展[J].中华放射医学与防护杂志,2018,38(5):390-394 |
| 白藜芦醇的放射防护作用及其机制研究进展 |
| Radioprotective effects of resveratrol and its mechanism |
| 投稿时间：2017-08-30 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.05.013 |
| 中文关键词: 白藜芦醇 电离辐射 防护 机制 |
| 英文关键词:Resveratrol Ionizing radiation Protection Mechanism |
| 基金项目:国家自然科学基金（31670859）；中央高校基本科研业务费专项资金（3332016100） |
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| 中文摘要: |
| 白藜芦醇作为一种天然活性物质，具有较强的抗氧化性和放射防护作用。体内外研究表明，白藜芦醇能够减轻放射损伤，在放射防护方面发挥着重要作用，具有良好的应用前景。本文就白藜芦醇对造血系统、免疫系统、神经系统、呼吸系统以及其他器官的放射防护作用和其作用机制进行综述。主要包括HO1信号通路、Nrf2途径等抗氧化机制以及激活Sirt1调节下游信号、促使TyrRs入核等发挥放射防护的作用，并对白藜芦醇的应用前景进行了展望。 |
| 英文摘要: |
| Resveratrol is a kind of natural active substance, which has strong antioxidant activity and radioprotective effect. A large number of tests have shown that resveratrol can attenuates radiation damage and play an important role in radiation protection, has a good application prospects. This paper reviews the radioprotective effects of resveratrol on the hematopoietic system, the immune system, the nervous system, the respiratory system, and other devices and their mechanisms of action. Including the HO1 signaling pathway, Nrf2 pathway and other antioxidant mechanisms and the activation of Sirt1 regulate the downstream signals, promote TyrRs into the nucleus to play the role of radioprotection. The prospect of application of resveratrol was also prospected. |
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