| 林仲武,王琪,王治东.辐射生物剂量计的研究现状及发展方向[J].中华放射医学与防护杂志,2017,37(10):799-804 |
| 辐射生物剂量计的研究现状及发展方向 |
| Overview of current situation and future development of radiation biodosimetry study |
| 投稿时间：2017-06-28 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.10.015 |
| 中文关键词: 辐射生物剂量计 细胞遗传学技术 γ-H2AX 分子标志物 |
| 英文关键词:Radiation biodosimeter Chromosome aberration γ-H2AX Molecular biomarker |
| 基金项目:军队医学科技青年培育项目（15QNP089）；全军后勤科研重大专项（AWS14C014） |
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| 中文摘要: |
| 辐射生物剂量学是放射医学的重要组成部分。近年来，辐射生物剂量研究取得一些新进展，为研发新一代剂量计奠定技术基础。以染色体畸变分析为代表的细胞遗传学方法作为辐射生物剂量估算的金标准方法，正向自动化、网络化分析发展，相关技术已通过国际和国家性的辐射生物剂量实验室网络辐射扩散。γ-H2AX作为DNA损伤的标志性分子，用于放射损伤剂量估算的研究进展较快，其作为放射损伤分子标志物逐步获得国内外的广泛共识。在蛋白分子和表达基因的基础上，代谢物和miRNA作为放射损伤标志物的研究有进一步的新进展。组学技术的发展，推动了利用多分子表达谱评估受照剂量的研究，亦已取得突破。本文从现有辐射生物剂量计的技术特点、国内外的主要发展趋势和今后发展方向展望等3个方面进行综述。 |
| 英文摘要: |
| Radiation biodosimetry is an important part of radiation medicine. Some new discoveries and progresses have been made in radiation biodosimetry studies in recent years. Cytogenetic method represented by chromosome aberration analysis as the golden standard of radiation biodosimeter is being transformed to automate analysis, and a number of international, regional and national laboratory networks of radiation biodosimetry are being established. As a widely acceptable molecular marker of DNA damage, γ-H2AX has made rapid progress in radiation dose estimation. Based on the expressions of protein and genes, further advancements have been made in the studies of metabolites and miRNAs. At the same time, with the development of proteomics technology, there are some breakthroughs in the study of using molecular expression profiling to evaluate radiation dose. The research progresses of radiation biodosimetry is reviewed in this paper. |
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