| 潘天帆,陆建,王勇,等.放射性125Ⅰ粒子组织间植入治疗盆腔恶性肿瘤的研究进展[J].中华放射医学与防护杂志,2017,37(7):557-561.Pan Tianfan,Lu Jian,Wang Yong,et al.Research progress of 125Ⅰ radioactive seed interstitial brachytherapy in the treatment for pelvic malignancies[J].Chin J Radiol Med Prot,2017,37(7):557-561 |
| 放射性125Ⅰ粒子组织间植入治疗盆腔恶性肿瘤的研究进展 |
| Research progress of 125Ⅰ radioactive seed interstitial brachytherapy in the treatment for pelvic malignancies |
| 投稿时间：2017-04-26 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.07.016 |
| 中文关键词: 125Ⅰ 近距离放射治疗 盆腔恶性肿瘤 放射治疗计划 3D打印 |
| 英文关键词:125Ⅰ Brachytherapy Pelvic malignancies Radiation treatment planning Three dimensional printing |
| 基金项目:国家自然科学基金（81471762）；江苏省省级重点研发专项资金（BE2016783） |
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| 中文摘要: |
| 放射性 125Ⅰ粒子组织间植入具有低剂量率、持续照射、可反复植入等特点，目前常应用于宫颈癌的治疗，也适用于卵巢癌、结直肠癌、膀胱癌等盆腔恶性肿瘤。与外放疗相比，125Ⅰ粒子近距离治疗可提高肿瘤靶区剂量，有效控制局部肿瘤，同时保护周围正常组织，减少并发症。现从 125Ⅰ粒子组织间植入治疗盆腔恶性肿瘤的特性、作用机理、并发症以及临床应用的最新进展进行综述，同时介绍3D打印模板在粒子植入中的应用，为临床广泛推广提供一定的参考。 |
| 英文摘要: |
| Brachytherapy with 125Ⅰ radioactive seed has the advantages of low dose-rate,comtinuous irradiation and repeated implantation to inhibit the replication of tumor cells, and the repeatable implantation. It has been widely used in the treatment for cervial cancer, and can also be applied to pelvic malignancies, including ovarian cancer, colorectal cancer, bladder cancer. Compared with external beam radiotherapy, it can improve the dose of target region to control tumor effectively. At the same time,it can protect the normal tissues and reduce the occurrence of complications. In this paper, we summarized the specialty, function mechanism, complications and application status of radioactive 125Ⅰ seed interstitial implantation in the treatment of pelvic malignancies. The application of three dimensional printing in brachytherapy with radioactive 125Ⅰ seed was also introduced.This review can provide a reliable basis for future standardized seed implantation treatment for pelvic malignancies. |
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