| 彭倩,王培,王先良,等.宫颈癌后装治疗中图形优化与逆向模拟退火优化剂量学分析[J].中华放射医学与防护杂志,2016,36(12):909-912.Peng Qian,Wang Pei,Wang Xianliang,et al.Comparison of graphical optimization and inverse planning simulated annealing for brachytherapy of cervix cancers[J].Chin J Radiol Med Prot,2016,36(12):909-912 |
| 宫颈癌后装治疗中图形优化与逆向模拟退火优化剂量学分析 |
| Comparison of graphical optimization and inverse planning simulated annealing for brachytherapy of cervix cancers |
| 投稿时间：2016-06-28 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.12.006 |
| 中文关键词: 宫颈癌 后装 图形优化 模拟退火逆向优化 剂量学 |
| 英文关键词:Cervix cancer Brachytherapy Graphical optimization Inverse simulated annealing optimization Dosimetry |
| 基金项目:四川省科技支撑计划项目（2014SZ0001） |
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| 中文摘要: |
| 目的 比较宫颈癌三维后装计划中图形优化（GO）和模拟退火逆向优化（IPSA）剂量分布的差异，为宫颈癌后装治疗计划优化方法的选择提供依据。方法 利用Excel 2007产生的随机数，从已完成治疗的根治性宫颈癌患者中选取21例，原后装治疗计划采用图形优化，基于原图像信息，制定IPSA计划，统计临床靶区（CTV）剂量体积参数V100%、V150%，以及均匀性指数（HI）、适形指数（CI）、膀胱和直肠的D1 cm3、D2 cm3，对比两种优化方法的剂量特点。结果 两个计划的靶区剂量均能满足处方要求，所有靶区剂量参数的均值接近，差异无统计学意义（P>0.05）。与GO计划相比，IPSA计划中膀胱D1 cm3、D2 cm3的剂量明显降低（t=3.596、3.490，P<0.05）；直肠剂量参数的差异无统计学意义（P>0.05）。结论 在宫颈癌三管后装治疗中，采用GO和IPSA对靶区无影响，但IPSA可以减小膀胱的最大受量。 |
| 英文摘要: |
| Objective To compare the differences and characteristics of the dose distribution of the two optimization methods in the three dimensional brachytherapy, and provide the basis for clinical treatment. Methods Excel 2007 was used to generate random number. And a total of 21 patients of cervical cancer were selected from those who have completed the treatment. Inverse simulated annealing optimization (IPSA) plans were designed for graphical optimization (GO) plans. The dose volume histogram (DVH) parameters of the targets (V100%, V150%) and the organs (D1 cm3, D2 cm3) of the two methods were analyzed. Results The targets dose of both plans could meet the prescription requirements. There was no statistically significant difference in the dose parameters of all targets (P>0.05).The doses of D1 cm3 and D2 cm3 in the bladder of IPSA plan were significantly lower than that of the GO plan (t=3.596, 3.490, P<0.05).There was no statistically significant difference in the dose parameters of rectum (P>0.05). Conclusions For cervix brachytherapy, the GO and IPSA have no effect on targets dose, but IPSA optimization can reduce the maximum dose of bladder. |
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