| 丁昕,田野.放射性海马功能障碍的研究现状[J].中华放射医学与防护杂志,2016,36(9):712-716.Ding Xin,Tian Ye.Research status of hippocampal dysfunctions caused by cranial irradiation[J].Chin J Radiol Med Prot,2016,36(9):712-716 |
| 放射性海马功能障碍的研究现状 |
| Research status of hippocampal dysfunctions caused by cranial irradiation |
| 投稿时间：2016-04-18 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.09.017 |
| 中文关键词: 放射治疗 海马功能障碍 神经发生 |
| 英文关键词:Cranial radiation Hippocampal dysfunction Neurogenesis |
| 基金项目:国家自然科学基金（81372411，81402517） |
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| 中文摘要: |
| 颅脑放疗在脑部肿瘤的治疗中常规应用，但可能会造成不同程度的放射性脑损伤，尤其是对具有认知和情绪调控功能的海马组织。目前的研究表明，放射性海马功能障碍的发病机制可能与神经发生、神经营养因子以及神经炎症相关，并提出运动锻炼、丰富环境、抗炎治疗和神经干细胞移植等可能有效的防治策略。本文将放射性海马功能障碍的研究进展及面临的挑战进行综述，旨在为未来的基础和临床研究提供有利的切入点。 |
| 英文摘要: |
| Cranial irradiation is routinely used for the treatment of almost all brain tumors, but it may cause disastrous injury in brain, especially in the hippocampus that has cognitional and emotional regulation functions. Several studies have investigated the mechanisms of radiation-induced hippocampal dysfunctions such as hippocampal neurogenesis, neurotrophin and neuroinflammation, and provided effective prevention strategies such as exercise, environmental enrichment, anti-inflammatory and intrahippocampal transplantation of neural stem cells. This review discussed the current progresses and challenges of hippocampal dysfunction induced by cranial irradiation and provided new insights for preclinical and clinical researches. |
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