| 王谨,陈明.质子及重离子治疗肿瘤的现状及研究进展[J].中华放射医学与防护杂志,2016,36(8):616-620 |
| 质子及重离子治疗肿瘤的现状及研究进展 |
| Proton and heavy ion radiotherapy: the context and challenges |
| 投稿时间：2016-03-16 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.08.012 |
| 中文关键词: 质子 重离子 Bragg峰 放射治疗 |
| 英文关键词:Proton Heavy ion Bragg peak Radiotherapy |
| 基金项目:浙江省自然科学基金青年项目（LQ14H160005） |
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| 中文摘要: |
| 质子和重离子射线治疗肿瘤，是利用质子和重离子穿过物质形成Bragg峰的物理特性和重离子优越的放射生物学特性，将高剂量区调整嵌合在肿瘤上，同时尽量避开周围正常组织器官。质子及重离子放疗剂量分布优于光子放疗，这有利于提升肿瘤剂量和降低正常组织损伤。近年来，不少研究探索了质子重离子治疗头颈部肿瘤、肺癌、食管癌、肝癌等肿瘤的有效性及安全性，而多个对比光子及质子治疗肿瘤的临床研究也正在进行中。这些研究的结果将有利于更好地了解质子及重离子治疗的特点及优势，以便筛选合适的患者，合理推广质子重离子放疗。 |
| 英文摘要: |
| Protons and heavy ion radiation therapy have proven highly effective against a wide range of cancers and in recent decades there have been rapid advances. Due to the physical characteristics of the Bragg-peak and superior biological properties, proton and heavy ion radiation is able to focus its energy on the tumor while minimizing exposure to surrounding normal tissues and organs, which is expected help enhance the tumor dose and reduce normal tissue damage. In recent years, many studies have explored the efficacy and safety of proton and heavy ion radiotherapy on various malignancies, such as head and neck cancer, lung cancer, esophageal cancer, and liver cancer. The results of these studies enable a better understanding of the characteristics and advantages of proton and heavy ion therapy. |
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