| 张朦,周菊英.NF-κB在放射性损伤中的表达改变及作用机制的研究进展[J].中华放射医学与防护杂志,2016,36(7):553-557 |
| NF-κB在放射性损伤中的表达改变及作用机制的研究进展 |
| The progresses of mechanistic studies of the effect of NF-κB on radiation damage |
| 投稿时间：2015-09-22 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.07.016 |
| 中文关键词: 核转录因子-κB 放射性损伤 NF-κB抑制剂 |
| 英文关键词:NF-κB Radiation damage NF-κB inhibitor |
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| 摘要点击次数: 2404 |
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| 中文摘要: |
| 随着肿瘤发病率的升高，需要接受放射治疗的人数也越来越多；而且由于放射治疗技术的不断发展，患者的长期生存期也在不断延长。因此，在长期生存的患者中防止放射性损伤的发生就尤为重要。NF-κB在各种基因转录的过程中承担着重要作用，并与放射性损伤的发生有着密切关系。笔者就NF-κB的结构、激活、功能作一介绍，并对放射性脑损伤及放射性肺损伤中NF-κB的表达变化、调节机制，以及NF-κB抑制剂的研究进展作一综述。 |
| 英文摘要: |
| The number of people needed to accept radiotherapy is increasing with the higher incidence of tumor, and the continuous development of radiation therapy technology has extended the long-term survival of patients. Avoiding the occurrence of radiation damage is particularly important. Since NF-κB plays an important role in gene transcription and regulation of radiation damage, this article introduced the structure, activation and function of NF-κB, reviewed the findings of NF-κB alterations in radiation injuries of brain and lung, and sketched the studies of NF-κB inhibitor. |
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