| 张巍,罗毅,李洁清,柳怡.18F-FDG-PET/CT长期照射对兔免疫指标的影响[J].中华放射医学与防护杂志,2016,36(4):264-267 |
| 18F-FDG-PET/CT长期照射对兔免疫指标的影响 |
| Effects of long term exposure of 18F-FDG-PET/CT on rabbit immune system |
| 投稿时间：2015-07-02 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.04.006 |
| 中文关键词: 18F-FDG-PET/CT 长期照射 免疫系统 |
| 英文关键词:18F-FDG-PET/CT Long-term irradiation Immune system |
| 基金项目:北京市医院管理局临床医学发展专项(ZYLX201509) |
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| 中文摘要: |
| 目的 探讨18F-氟代葡萄糖正电子发射断层扫描术计算机层析成像(18F-FDG-PET/CT)长期反复扫描对动物免疫系统的影响。方法 取成年大耳白兔,分为健康对照组和实验组。实验组以18F-FDG-PET/CT每天连续照射3个月,期间分别于第1、2和3个月,对兔免疫系统包括白细胞总数、胸腺系数与脾脏指数、巨噬细胞吞噬功能、血清 IgG、IgM、IgA 含量、血浆TNF-α和IL-1β水平分别进行测定。结果 18F-FDG-PET/CT长期照射条件下,实验组与健康对照组比较,白细胞总数增加,而脾脏和胸腺指数下降(t=3.144~72.903,P<0.05);照射1个月后巨噬细胞吞噬百分率、照射2~3个月后的吞噬指数与吞噬百分率与健康对照组比较出现下降(t=2.719~11.859,P<0.05);免疫T细胞CD4+和CD8+分别在照射2个和1个月后出现升高和降低(t=6.433~29.877,P<0.05);血清免疫球蛋白含量在长期照射后出现不同程度的下降(t=2.720~28.775,P<0.05),血清TNF-α、IL-1β蛋白表达亦与健康对照组存在明显差异。结论 18F-FDG-PET/CT对健康成年雄性日本大耳白兔长期照射对动物的免疫系统有一定的影响,在临床应用上应该注意其对人体的辐射效应。 |
| 英文摘要: |
| Objective To investigate the effects of long term exposure of 18F-FDG-PET/CT X-rays on rabbit immune system. Methods The rabbits were irradiated with 18F-FDG-PET/CT every day and this irradiation treatment continued for 3 months. At each month, the total number of white blood cells, thymus index and spleen index, phagocytic index, immune globulins, TNF-α and IL-1 in peripheral blood and serum were detected. Results After long-term 18F-FDG-PET/CT irradiation, the total number of white blood cells increased, the thymus and spleen index decreased (t=3.144-72.903, P<0.05), the phagocytic index and phagocytic percentage decreased after 1 or 2 months(t=2.719-11.859, P<0.05), and the number of immune cells marked with CD4+ increased but CD8+ decreased(t=6.433-29.877, P<0.05). In addition, the level of immune globulin in the serum decreased, but the expressions of TNF-α and IL-1β increased (t=2.720-28.775, P<0.05). Conclusions 18F-FDG-PET/CT has some damage effects on the immune system of male Japanese big ear rabbit, suggesting that the negative effects of PET-CT should be paid close attention to during clinical application. |
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