| 沈关驻,邓小武,吴少雄,肖巍魏,韩非,李安川,赵充.采用风险分类分析局部中晚期鼻咽癌单纯调强放疗疗效[J].中华放射医学与防护杂志,2015,35(7):518-521 |
| 采用风险分类分析局部中晚期鼻咽癌单纯调强放疗疗效 |
| Application of risk category system to evaluate the treatment outcome of locoregionally advanced nasopharyngeal carcinoma treated by intensity-modulated radiation therapy alone |
| 投稿时间：2015-03-04 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.07.009 |
| 中文关键词: 调强放疗 鼻咽癌 风险分类 |
| 英文关键词:Intensity-modulated radiation therapy Nasopharyngeal carcinoma Risk category |
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| 中文摘要: |
| 目的 探讨采用风险分类方法评估局部中晚期鼻咽癌单纯调强放疗疗效的可行性,为前瞻性研究提供依据。 方法 将185例接受单纯调强放疗的局部中晚期鼻咽癌病例,按治疗后死亡风险分为高危组和低危组(无高危因素),高危因素包括下列之一:GTVnx > 30 cm3;T4N2M0期;颈部多个淋巴结转移,其中一个短径 > 4 cm,以及任何T和N3M0期。分析和比较两组病例的临床疗效。 结果 中位随访时间110.9个月(6.7~152.4个月)。高危组和低危组的5年总生存率、局部区域无复发生存率、无远处转移生存率分别为61.0%和90.5%(χ2=30.298,P<0.05)、78.3%和91.5%(χ2=6.352,P<0.05)、71.6% 和92.0%(χ2=16.346,P<0.05)。 结论 该风险分类方法简单易行,可以区分局部中晚期鼻咽癌中的不同失败风险病例,有利于指导临床有针对性开展前瞻性研究。 |
| 英文摘要: |
| Objective To explore the feasibility of employing a risk category system in evaluating the treatment outcome of locoregionally advanced nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiation therapy (IMRT) alone, and offering evidence for relevant perspective studies. Methods Totally 185 locoregionally advanced NPC patients were divided into high-risk and low-risk groups for evaluation and comparison. The patients who met at least one of the following criteria were defined as high-risk group and others as low-risk group: GTVnx>30 cm3; Clinical stage T4N2M0; multiple neck node metastases with 1 node size >4 cm, and N3 with any T stage. Results With a median follow up of 110.9 months (6.7-152.4 months), the 5-year overall survival, locoregional relapse-free survival, distant metastasis-free survival for thehigh-risk group vs. the low-risk group were 61.0% vs.90.5%(χ2=30.298,P<0.05), 78.3% vs. 91.5%(χ2=6.352,P<0.05)and 71.6% vs. 92.0%(χ2=16.346,P<0.05). Conclusions As a simple and practicable method, the risk category system is helpful for discriminating locoregionally advanced nasopharyngeal carcinoma with different risk-group of treatment failure and in further perspective clinical research. |
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