| 王福如,余宁乐,刘宇飞,徐小三,傅颖华,孙全富.江苏省医用X射线工作者1950—2011年间恶性肿瘤发生风险研究[J].中华放射医学与防护杂志,2015,35(6):449-454 |
| 江苏省医用X射线工作者1950—2011年间恶性肿瘤发生风险研究 |
| Incidence risks of malignant tumor among medical diagnostic X-ray workers during 1950-2011 in Jiangsu, China |
| 投稿时间：2014-03-25 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.06.011 |
| 中文关键词: 医用X射线工作者 队列研究 恶性肿瘤 相对危险 辐射致癌 |
| 英文关键词:Medical X-ray workers Cohort study Malignant tumor Relative risk Radiation carcinogenesis |
| 基金项目:卫生行业科研专项(201002009) |
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| 中文摘要: |
| 目的 研究江苏省医用X射线工作者的职业性照射因素与恶性肿瘤发病风险之间的关系。方法 采用回顾性和前瞻性队列相结合的研究方法,选取省内1950—1980年间在医院放射科工作的医用X射线工作者为放射组;同一医院同时期未从事过放射工作的内科、五官科、儿科等医务人员为对照组形成调查队列。计算该随访队列1950—2011年累计观察人年数,并采用Poisson回归模型,计算调整性别、年龄等因素后医用X射线工作者的各种恶性肿瘤的相对危险。结果 本次队列共完成随访7 703人,其中放射组3 961人,对照组3 742人,总体观察人年数为315 309人年,失访率为6.92%(533/7 703)。1950—2011年期间肿瘤患者共计819人(恶性肿瘤771人),放射组恶性肿瘤发病风险明显高于对照组,实体癌和全部恶性肿瘤的相对危险度RR分别为1.31(95%CI:1.11~1.55)和1.33(95%CI:1.13~1.57)。其中放射组罹患肺癌的相对危险度明显提高(RR=1.45,95%CI:1.00~2.09)。结论 江苏省医用X射线工作者罹患肺癌、实体癌以及全癌的相对危险度明显提高,可能与其长期接受慢性小剂量职业照射有关。 |
| 英文摘要: |
| Objective To study the relationship between the risk of malignant tumor and occupational radiation factor among medical diagnostic X-ray workers in Jiangsu province. Methods The retrospective and prospective cohort studies were adopted to investigate the incidence of cancer. Eligible medical diagnostic X-ray workers from the department of radiology in hospitals were selected and assigned into exposure group, while other medical workers from the departments of Internal Medicine, Ear-Nose-Throat (ENT) or Pediatrics who attended work at the same period in the same hospital but not engaged in radiation work were regarded as control group during 1950-2011 in Jiangsu province. We calculated the total person-year and analyzed the relative risk (RR) of malignant tumor using Poisson regression model. Results 7 703 participants (3 961 in exposed group and 3 742 in unexposed group) were recruited and followed up, with a total of 315 309 person years and the lost follow-up rate was 6.92% (533/7 703). During the follow up period, a total of 819 tumor cases were identified (771 were malignant tumors). We found the significant relationship between the risk of malignant tumor and occupational radiation factor, and the RR of solid cancer and total malignant tumor were 1.31 (95%CI:1.11-1.55) and 1.33 (95%CI:1.13-1.57), respectively. In addition, the risk of lung cancer in medical diagnostic X-ray workers was significantly higher than that in control group (RR=1.45,95%CI:1.00-2.09). Conclusions The incidence risk of lung cancer, solid caner and total malignant tumors in medical diagnostic X-ray workers was significantly higher than that in the control group, which might be associated with occupational exposure to ionizing radiation. |
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