| 李志,姜杉,杨志永,等.基于实验与蒙特卡罗模拟法探究125I粒子间剂量衰减[J].中华放射医学与防护杂志,2015,35(5):389-392.Li Zhi,Jiang Shan,Yang Zhiyong,et al.Monte Carlo simulation and experimental investigation of 125I interseed dose attenuation[J].Chin J Radiol Med Prot,2015,35(5):389-392 |
| 基于实验与蒙特卡罗模拟法探究125I粒子间剂量衰减 |
| Monte Carlo simulation and experimental investigation of 125I interseed dose attenuation |
| 投稿时间：2014-09-03 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.05.019 |
| 中文关键词: 近距离放疗 125I粒子 剂量衰减 Geant 4 蒙特卡罗 |
| 英文关键词:Brachytherapy 125I seed dose attenuation Geant 4 Monte Carlo |
| 基金项目:国家自然科学基金(51175373);天津市科技支撑重大项目(12ZCDZSY10600) |
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| 中文摘要: |
| 目的 研究多颗125I放射性粒子间剂量衰减规律.方法 利用Geant 4软件包进行蒙特卡罗模拟单颗粒子和多颗粒子周围剂量分布,将模拟结果与TG43-U1报告中推荐剂量计算方法所得结果进行对比,并利用实验测得数据验证蒙特卡罗模拟结果.结果 单颗粒子周围剂量分布的蒙特卡罗模拟结果与TG43-U1计算和实验结果差值分别在±3%和±5%以内.多颗粒子的蒙特卡罗模拟结果对比TG43-U1线性叠加结果,粒子间剂量衰减为3.8%~13.2%,平均剂量衰减为7.2%,实验所得结果与蒙特卡罗模拟结果差值在6%以内.结论 空间中存在多颗放射性125I粒子时,由于粒子间的相互影响导致7%左右的剂量衰减,其最大值可超过13%,在人体组织中剂量衰减值会更大.因此,利用TG43-U1方法进行线性叠加计算临床中的剂量分布不够精确. |
| 英文摘要: |
| Objective To investigate the interseed dose attenuation for multiple 125I seeds. Methods Monte Carlo simulation was done by Geant 4 to investigate the dose distribution of single seed and multiple seeds. The results were compared with the dose calculation method from TG43-U1 and examined by experiments. Results The difference of single seed dose distribution between Monte Carlo method and line source model was ± 3%. The difference between Monte Carlo method and experiment result was ± 5%. The interseed dose attenuation of multiple seeds at the interesting points was 3.8% to 13.2% and the average interseed dose attenuation was 7.2%. The difference of experiment result and Monte Carlo result was less than 6%. Conclusions The interseed attenuation is about 7% and the maximum value may be larger than 13% for multiple seeds. The interseed dose attenuation may be larger in tissue. So it is not accurate to calculate the dose distribution by using TG43-U1. |
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