| 沈文斌,高红梅,祝淑钗,李幼梅,曹彦坤,刘志坤,李曙光,苏景伟,李娟.选择性区域淋巴结照射对临床早期食管癌放疗疗效的影响[J].中华放射医学与防护杂志,2015,35(4):265-269 |
| 选择性区域淋巴结照射对临床早期食管癌放疗疗效的影响 |
| Analysis on efficacy of different radiotherapy methods in no-metastasis esophageal squamous cell carcinoma |
| 投稿时间：2014-06-29 |
| DOI：10.3760/cma.j.issn.0254-5098.2015.04.007 |
| 中文关键词: 食管鳞癌 放疗方式 疗效 |
| 英文关键词:Esophageal neoplasms Radiotherapy mode Efficacy |
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| 中文摘要: |
| 目的 评价临床无转移且病变长度≤5.0 cm的食管鳞癌(ESCC)接受不同放疗方式治疗的疗效.方法 对符合入组条件的158例临床无转移且病变长度≤5.0 cm的ESCC患者进行回顾性分析,分析不同治疗方式对此部分患者的治疗疗效、预后因素及不良反应等的影响.结果 选择性淋巴结照射(ENI)与累及野照射(IFI)组患者近期疗效差异无统计学意义.与IFI患者相比,ENI患者的总生存率(OS)及肿瘤特异性生存率(TSS)提高(χ2=11.21、8.57,P<0.05),而局部复发率(LR)及远处转移率(DM)降低(χ2=4.99、7.48,P<0.05).多因素分析结果显示,ECOG分级和近期疗效为IFI组患者的独立性预后影响因素(χ2=15.05、10.32,P<0.05),CT显示食管病变最大直径为ENI组患者的独立性预后影响因素(χ2=8.32,P<0.05).ENI与IFI患者出现≥2级急性放射性食管炎(RE)及放射性肺炎(RP)的差异均无统计学意义.结论 放化疗对于临床无转移且病变长度≤5.0 cm的ESCC患者有较好疗效,ENI较IFI更可能给患者的生存带来益处. |
| 英文摘要: |
| Objective To evaluate the curative effect of different radiotherapy methods in no-metastasis and lesion length ≤ 5.0 cm esophageal squamous cell carcinoma (ESCC). Mothods A total of 158 eligible patients were retrospectively analyzed. The treatment out comes prognosis factors, and toxicity were evaluated. Results There were no significantly differences in curative effect for ENI and IFI group(χ2=2.17,P>0.05). Compared with IFI group, the OS and TSS were significantly higher than in ENI group (χ2=11.21, 8.57, P<0.05), and the LR ratio and DM ratio were significantly lower than that of the IFI patients (χ2=4.99, 7.48, P<0.05). Multivariate analysis showed that ECOG grade and short-term effect (χ2=15.05,10.32,P<0.05) were the independent prognostic factor for IFI, while the maximum diameter of CT(χ2=8.32,P<0.05) was the independent prognostic factor for ENI. There were no significant differences in acute radiation esophagitis and pneumonitis between ENI and IFI groups. Conclusions Radiotherapy in combination with chemotherapy has a good curative effect in no-metastasis and lesion length ≤ 5.0 cm ESCC patients. More survival benefit might be achieved by ENI than IFI. |
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