| 王超,冯洪燕,肖雄,等.68Ga-FAPI PET/CT受检者周围剂量当量率的分布与周围人员受照剂量估算[J].中华放射医学与防护杂志,2026,46(9):872-877.Wang Chao,Feng Hongyan,Xiao Xiong,et al.Distribution of the ambient dose equivalent rate around patients undergoing 68Ga-fibroblast activation protein inhibitor positron emission tomography/computed tomography and estimation of radiation doses to nearby personnel[J].Chin J Radiol Med Prot,2026,46(9):872-877 |
| 68Ga-FAPI PET/CT受检者周围剂量当量率的分布与周围人员受照剂量估算 |
| Distribution of the ambient dose equivalent rate around patients undergoing 68Ga-fibroblast activation protein inhibitor positron emission tomography/computed tomography and estimation of radiation doses to nearby personnel |
| 投稿时间：2026-03-29 |
| DOI：10.3760/cma.j.cn112271-20260329-00120 |
| 中文关键词: 68Ga-FAPI 周围剂量当量率 有效剂量 |
| 英文关键词:68Ga-fibroblast activation protein inhibitor Ambient dose equivalent rate Effective dose |
| 基金项目:国家重点研发计划资助（2024YFC2419400）；中央高校基本科研业务费专项资金（2042025KF0005） |
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| 中文摘要: |
| 目的 分析注射68Ga-FAPI后PET/CT受检者周围剂量当量率的分布特征，并估算其对周围人员的辐射剂量水平。方法 纳入30例接受68Ga-FAPI PET/CT检查的受检者，于注射后0、0.5、1、1.5、2、3 h，分别测量距受检者0.25、0.5、1、2、3、4 m处的周围剂量当量率。采用经验幂函数模型拟合剂量当量率与距离的关系，采用指数衰减模型分析剂量当量率随时间的变化规律，并依据剂量转换系数估算周围人员所受的有效剂量。结果 各时间点周围剂量当量率均随距离增加显著衰减，注射后0、0.5、1、1.5、2、3 h的拟合幂值分别为-1.73、-1.71、-1.83、-1.81、-1.79、-1.75；周围剂量当量率随时间呈指数衰减，距离受检者1 m处的衰减常数λ为0.74 h-1，对应有效半衰期为56 min；注射后0、1、2、3 h，距受检者1 m处停留10 min所致周围人员有效剂量分别为3.14、1.39、0.79、0.32 μSv。结论 68Ga-FAPI PET/CT受检者周围剂量当量率随距离增加和时间延长均迅速降低，其对周围人员的辐射剂量均低于国家标准规定的有效剂量约束值。 |
| 英文摘要: |
| Objective To analyze the distribution characteristics of the ambient dose equivalent rate around patients undergoing 68Ga-fibroblast activation protein inhibitor positron emission tomography/computed tomography (68Ga-FAPI PET/CT) and estimate the resultant radiation doses to nearby personnel.Methods A total of 30 patients who underwent 68Ga-FAPI PET/CT were enrolled. Ambient dose equivalent rate were measured at distances of 0.25, 0.5, 1, 2, 3, and 4 m from the patients at 0, 0.5, 1, 1.5, 2, and 3 h after injection of 68Ga-FAPI. An empirical power function model was used to fit the relationship between ambient dose equivalent rate and distance, and an exponential decay model was applied to analyze the temporal variation in ambient dose equivalent rate. Based on dose conversion coefficients, the effective doses received by nearby personnel were estimated.Results At all time points, the ambient dose equivalent rate decreased significantly with increasing distance. The fitted power exponents at 0, 0.5, 1, 1.5, 2, and 3 h post-injection were -1.73, -1.71, -1.83, -1.81, -1.79, and -1.75, respectively. The ambient dose equivalent rate exhibited an exponential decay over time, with an attenuation constant λ of 0.74 h-1 at 1 m from the patient, corresponding to an effective half-life of 56 min. At 0, 1, 2, and 3 h post-injection, a 10 min stay at 1 m from the patient resulted in effective doses to nearby personnel of 3.14, 1.39, 0.79, and 0.32 μSv, respectively.Conclusions The ambient dose equivalent rate around patients undergoing 68Ga-FAPI PET/CT declines rapidly with both increasing distance and elapsed time. The radiation doses to nearby personnel are all below the effective dose constraints specified by national standards. |
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