| 路天翔,朱夫海,赵锡鹏,等.金活化法测量硼中子俘获治疗中子注量特性的研究与应用[J].中华放射医学与防护杂志,2026,46(8):781-787.Lu Tianxiang,Zhu Fuhai,Zhao Xipeng,et al.Application of a gold foil activation-based method for measuring neutron fluence for BNCT[J].Chin J Radiol Med Prot,2026,46(8):781-787 |
| 金活化法测量硼中子俘获治疗中子注量特性的研究与应用 |
| Application of a gold foil activation-based method for measuring neutron fluence for BNCT |
| 投稿时间：2026-02-25 |
| DOI：10.3760/cma.j.cn112271-20260225-00062 |
| 中文关键词: γ能谱|硼中子俘获治疗|效率刻度|金活化法|质量控制检测 |
| 英文关键词:Gamma ray spectrum|Boron neutron capture therapy|Efficiency calibration|Gold foil activation method|Quality control testing |
| 基金项目:中国辐射防护研究院自主科研项目(TNMPP-2025-01) |
| 作者 | 单位 | E-mail | | 路天翔 | 国家卫生健康委职业安全卫生研究中心, 北京 102308 | | | 朱夫海 | 鹏博(海南)硼中子医院, 琼海 571430 | | | 赵锡鹏 | 国家卫生健康委职业安全卫生研究中心, 北京 102308 | | | 李玉文 | 国家卫生健康委职业安全卫生研究中心, 北京 102308 | | | 杨凯 | 中国辐射防护研究院, 太原 030006 | | | 熊强 | 国家卫生健康委职业安全卫生研究中心, 北京 102308 | | | 武钊 | 中国辐射防护研究院, 太原 030006 | | | 梁润成 | 中国辐射防护研究院, 太原 030006 | | | 张震 | 国家卫生健康委职业安全卫生研究中心, 北京 102308 | zhangzhen04@126.com | | 黄李涵 | 鹏博(海南)硼中子医院, 琼海 571430 | |
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| 摘要点击次数: 1895 |
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| 中文摘要: |
| 目的 建立一种基于γ能谱效率刻度与金活化法的硼中子俘获治疗(BNCT)设备中子注量特性测量方法,为BNCT中子注量质量控制检测提供技术参考。方法 利用高纯锗γ能谱仪,对152Eu点源在411.1 keV能量点进行有源效率刻度与无源效率刻度,并对198Au点源在411.8 keV能量点进行无源效率刻度,以相互验证效率值的准确性。采用金活化法,在水模体中沿束流轴线测量深度中子注量分布特性及照射野内的中子注量对称性,以152Eu在411.1 keV处的有源效率值替代198Au在411.8 keV处的效率值,计算活化金丝的单核反应率,并与设备出厂基线值进行对比。结果 152Eu在411.1 keV处的有源全能峰探测效率与无源模拟全能峰探测效率的相对偏差为2.40%,与198Au在411.8 keV处无源模拟全能峰探测效率的相对偏差为2.84%,两者均在标准源的不确定度(3%)范围内。深度中子注量特性显示,峰值位于水下19.5 mm处,9.5和57 mm深度处相对反应率与基线值的相对偏差分别为-3.77%和-0.65%,符合±5%的规范要求。照射野中子注量对称性:横向为98.7%~105.9%,纵向为99.9%~108.0%,最大偏差8.0%,符合±10%的规范要求。结论 基于金活化法建立的中子注量特性测量方法准确可靠,可用于BNCT设备的中子注量特性检测,为BNCT质量控制和稳定性检测提供了有效参考。 |
| 英文摘要: |
| Objective To develop a method for measuring the neutron fluence characteristics of boron neutron capture therapy (BNCT) devices based on gamma-spectroscopy efficiency calibration and gold foil activation, aiming to provide a technical reference for the quality control testing of neutron fluence for BNCT. Methods Using a high-purity germanium (HPGe) gamma spectrometer, this study conducted both active and sourceless efficiency calibrations for a 152Eu point source at 411.1 keV, as well as a sourceless efficiency calibration for a 198Au point source at 411.8 keV, aiming to determine the accuracy of the efficiency through cross-validation. Using the gold foil activation method, this study measured both depth-varying neutron fluence distribution along the beam axis and the neutron fluence symmetry within the irradiation field in a water phantom. By replacing the efficiency value of 198Au at 411.8 keV with the active efficiency value of 152Eu at 411.1 keV, the single nuclear reaction rates of the activated gold wires was calculated and compared with the ex-factory baseline values. Results The relative deviation between the active and sourceless simulated full-energy peak efficiency of 152Eu at 411.1 keV was determined at 2.40%, while that between the former and the sourceless simulated full-energy peak efficiency of 198Au at 411.8 keV measured 2.84%. Both deviations fell within the uncertainty range (3%) of the standard source. The depth-varying neutron fluence characteristics indicated that the single nuclear reaction rates of the activated gold wires peaked at a water depth of 19.5 mm. The relative deviations of the relative reaction rates at water depths of 9.5 and 57 mm from the baseline values were -3.77% and -0.65%, respectively, falling within the permissible error range of ±5% in relevant specifications. The neutron fluence in the irradiation field exhibited a lateral symmetry ranging from 98.7% to 105.9% and a vertical symmetry from 99.9% to 108.0%. The maximum deviation between the symmetries was 8.0%, falling within the threshold (±10%) in relevant specifications. Conclusions The gold foil activation-based method for measuring neutron fluence characteristics proves accurate and reliable. This method can be used to detect the neutron fluence characteristics of BNCT devices, thereby providing an effective reference for quality control and stability testing of BNCT. |
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