| 于静萍,孙志强,倪新初,王坚,李毅,胡莉钧,李栋庆,孙苏平.食管癌患者放疗前后血清血管内皮生长因子变化的临床意义[J].中华放射医学与防护杂志,2011,31(6):671-674 |
| 食管癌患者放疗前后血清血管内皮生长因子变化的临床意义 |
| Clinical significance of changes of serum vascular endothelial growth factor level before and after radiotherapy in patients with esophageal carcinoma |
| 投稿时间：2011-03-22 |
| DOI：10.3760/cma.j.issn.0254-5098.2011.06.013 |
| 中文关键词: 食管癌 放疗 血管内皮生长因子 |
| 英文关键词:Esophageal carcinoma Radiotherapy Vascular endothelial growth factor |
| 基金项目:常州市青年科技培养计划(CQ2008006);常州市社会发展指导性项目(CS2008920) |
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| 中文摘要: |
| 目的 检测食管癌患者放疗前、中、后血清血管内皮生长因子(VEGF)的水平,探讨其变化及临床意义。方法 采集67例食管癌患者和30例健康体检者(健康对照组)血清,应用酶联免疫吸附法(ELISA)测定VEGF水平,并对其变化与临床分期和患者放疗疗效的关系进行分析。结果 食管癌患者放疗前、中、后血清VEGF水平均较健康对照组升高,差异有统计学意义(F=11.65,P＜0.01);放疗后较放疗前VEGF水平明显降低,差异有统计学意义(F=10.72,P＜0.01)。T3、T4患者的平均VEGF水平与健康对照组比较显著升高,差异有统计学意义(F=14.10,P＜0.01)。N1、N2组患者的平均VEGF水平显著高于健康对照组,差异具有统计学意义(F=8.64,P＜0.01)。可评价疗效的62例患者中,有21例放疗后血清VEGF水平较放疗前升高,有41例较放疗前降低,升高组的放疗有效率为61.90%,降低组的放疗有效率为90.24%,两组比较差异有统计学意义(χ2=6.08,P＜0.05)。50例CR+PR患者放疗后及放疗中的血清VEGF水平均比放疗前显著降低,差异有统计学意义(F=7.98,P＜0.01)。结论 监测食管癌患者血清VEGF水平变化可判断患者放射治疗的敏感性,对临床预测放射治疗的预后有重要的意义。 |
| 英文摘要: |
| Objective To investigate the changes and clinical value of serum vascular endothelial growth factor (VEGF) level before, during and after radiotherapy in patients with esophageal carcinoma. Methods The sera of 67 esophageal carcinoma patients and 30 healthy control cases were collected.The VEGF level in serum samples were measured with enzyme-linked immunosorbent assay (ELISA) method.The relations among VEGF level changes, clinical stages and radiotherapy effect were analyzed. Results The VEGF levels of patients with esophagus cancer before, during and after radiotherapy were significantly higher than those in control group (F=11.65, P＜0.01). The VEGF level after radiotherapy was significant lower than that before radiotherapy(F=10.72, P＜0.01). The average VEGF level of patients with T3 and T4 was significantly higher than that of control group(F=14.10, P＜0.01). The average VEGF level of patients with N1 and N2 was significantly higher than that of control group(F=8.64, P＜0.01). In 62 patients,the serum VEGF level increased in 21 cases but decreased in 41 cases after radiotherapy. With difference in radiotherapy efficiency of 61.90% and 90.24%, respectively(χ2=6.08, P＜0.05).The average VEGF level during and after radiotherapy for 50 cases of CR+PR were significantly lower than that before radiotherapy(F=7.98,P＜0.01). Conclusions Monitoring the serum VEGF level of patients with esophagus cancer can help evaluate the radiosensitivity, which has a significance in predicting the prognosis of radiotherapy. |
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