| 王自夏,孟祥溪,张桢耀,等.18F-FDG自动给药系统减少职业辐射暴露和提高注射精度的研究[J].中华放射医学与防护杂志,2026,46(4):407-413.Wang Zixia,Meng Xiangxi,Zhang Zhenyao,et al.Automated 18F-FDG drug delivery system: Reducing occupational radiation exposure and improving injection accuracy[J].Chin J Radiol Med Prot,2026,46(4):407-413 |
| 18F-FDG自动给药系统减少职业辐射暴露和提高注射精度的研究 |
| Automated 18F-FDG drug delivery system: Reducing occupational radiation exposure and improving injection accuracy |
| 投稿时间：2025-04-09 |
| DOI：10.3760/cma.j.cn112271-20250409-00131 |
| 中文关键词: 自动给药系统|放射性药物|辐射防护|18F-FDG |
| 英文关键词:Automated drug delivery system|Radiopharmaceutical|Radiation protection|18F-FDG |
| 基金项目:国家自然科学基金(82472015,12505390);北京市医管局登峰人才计划(DFL20241103);北京市卫健委研究型病房卓越临床研究计划(BRWEP2024W032150102);国家重点研发计划(2022YFC2409405) |
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| 中文摘要: |
| 目的 比较手动注射与自动给药在18F-氟代脱氧葡萄糖 (2-[18F]-fluoro-2-deoxy-D-glucose;18F-FDG) 注射过程中注射精度、辐射暴露水平和操作区域表面污染的差异,评估自动给药系统在临床中的应用价值。方法 对2024年12月至2025年1月期间北京大学肿瘤医院核医学科行正电子发射计算机体层显像(positron emission tomography and computed tomography,PET/CT)检查并注射18F-FDG的患者,共504例(手动注射249例,自动给药255例),记录分装与注射剂量。注射过程中使用便携式辐射监测仪测量护士手臂(距针头 10 cm 处)和躯干(胸前位置)的周围剂量当量率峰值;注射结束后,测量并记录注射台、手套及地面 1 cm 处的表面周围剂量当量率峰值。结果 自动给药系统在注射精度、辐射暴露及操作区域污染控制方面均显著优于手动注射,各组间差异均 具有统计学意义(Z = -19.44~-3.16,P < 0.05)。手动注射与自动给药的注射活度偏差率为8.01%和0.83%;注射过程中手臂周围剂量当量率峰值平均为2 415和51.09 μSv/h,躯干平均为1.49和0.14 μSv/h;注射结束后注射台表面周围剂量当量率最大值分别为16.11和0.39 μSv/h,手套最大值分别为15.04和0.15 μSv/h;地面均处于本底水平。自动给药组所有区域未发生污染,而手动注射的注射台与手套污染发生率分别为7%和3%。结论 自动给药系统在注射精度、污染控制和辐射防护方面表现更为优越,有望提升临床操作的安全性。 |
| 英文摘要: |
| Objective To compare manual injection with an automated drug delivery system for 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) administration, focusing on injection accuracy, radiation exposure levels, and the surface contamination of operational areas, and to evaluate the clinical applicability of the automated injection system. Methods A total of 504 patients who underwent positron emission tomography/computed tomography (PET/CT) and 18F-FDG administration at the Department of Nuclear Medicine, Peking University Cancer Hospital & Institute between December 2024 and January 2025 were enrolled in this study. These patients were divided into two groups: the manual injection group (n = 249) and the automated delivery group (n = 255). The dispensed and injected doses of both groups were recorded. During the injection, the peak ambient dose equivalent rates (ADERs) at the nurse's arm (10 cm from the needle) and torso (anterior chest) were monitored using portable radiation monitoring instruments. Following the injection, the peak ADERs on the injection bench, gloves, and 1 cm above the floor were measured and recorded. Results The automated drug delivery system outperformed manual injection significantly in terms of injection accuracy, radiation exposure reduction, and contamination control in the operational areas, with statistically significant inter-group differences (Z = -19.44 to -3.16, P < 0.05) Specifically, the manual injection and automated delivery groups showed injected activity deviation rates of 8.01% and 0.83%, respectively. During injection, both groups exhibited average peak ADERs at the nurse's arm of 2 415 and 51.09 μSv/h and average peak ADERs at the torso of 1.49 and 0.14 μSv/h, respectively. After injection, both groups showed maximum ADERs on the bench surface of 16.11 and 0.39 μSv/h and maximum ADERs on the glove surface of 15.04 and 0.15 μSv/h, respectively. Meanwhile, for the two groups, the maximum ADERs 1 cm above the floor fell at the background levels. No surface contamination was detected in the automated delivery group. In contrast, contamination occurred at the bench and glove surfaces in the manual group, with incidences of 7% and 3%, respectively. Conclusions The automated 18F-FDG drug delivery system outperforms in terms of injection accuracy, environmental contamination control, and radiation protection. Therefore, this system is expected to enhance the safety of clinical operations. |
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