| 郑森兴,缪晓华,邹天禄,等.肝肿瘤树脂微球栓塞治疗后患者尿中90Y活度的测量和分析[J].中华放射医学与防护杂志,2026,46(4):396-400.Zheng Senxing,Miao Xiaohua,Zou Tianlu,et al.Measurement and analysis of 90Y radioactivity in the urine of patients following 90Y-labeled resin microsphere embolization treatment for liver tumors[J].Chin J Radiol Med Prot,2026,46(4):396-400 |
| 肝肿瘤树脂微球栓塞治疗后患者尿中90Y活度的测量和分析 |
| Measurement and analysis of 90Y radioactivity in the urine of patients following 90Y-labeled resin microsphere embolization treatment for liver tumors |
| 投稿时间：2025-03-18 |
| DOI：10.3760/cma.j.cn112271-20250318-00094 |
| 中文关键词: 90Y|树脂微球|尿液|放射性水平 |
| 英文关键词:90Y|Resin microsphere|Urine|Radioactivity level |
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| 中文摘要: |
| 目的 了解肝肿瘤经动脉树脂微球栓塞治疗后患者尿液中的90Y活度的变化情况,为患者放射防护管理提供数据支撑。方法 收集5位肝肿瘤经动脉90Y树脂微球栓塞治疗的用药活度信息和接受治疗后第1天(0~24 h)、第2天(24~48 h)、第3天(48~72 h)患者的尿液,测量尿样中的90Y放射性活度,以每天收集时间中点时尿液中90Y活度与初始注射药物活度之比计算排泄占比。结果 5位患者的用药量为0.630~3.000 GBq,前3 d尿液中90Y的排泄占比分别为0.1671%(0.1358%~0.2276%)、0.0099%(0.0067%~0.0125%)、0.0066%(0.0051%~0.0080%)。患者尿液中90Y的活度与用药量呈正相关,尿中90Y活度浓度与排尿量呈负相关。结论 肝肿瘤树脂微球栓塞治疗后患者尿液中的90Y活度和活度浓度较高,有必要进行合理处置并加强对病房的放射防护管理。 |
| 英文摘要: |
| Objective To understand the changes in 90Y radioactivity in the urine of patients following transarterial 90Y-labeled resin microsphere for the embolization treatment of liver tumors and to provide data for radiological protection management of the patients. Methods Five liver tumor patients treated with 90Y-labeled resin microspheres were selected in this study. Both the information on their administration dose and their urine samples at 1 d (0-24 h), 2 d (24-48 h), and 3 d (48-72 h) after treatment were collected. The 90Y radioactivity in the urine samples was determined. The excretion rate of 90Y was calculated as the ratio of the 90Y radioactivity in urine at the middle sampling time every day to the radioactivity of the medication initially injected. Results The administration doses to the five patients ranged from 0.630 to 3.000 GBq. The average urine excretion rates of 90Y in the first three days were determined at 0.1671% (0.1358%-0.2276%), 0.0099% (0.0067%-0.0125%), and 0.0066% (0.0051%-0.0080%), respectively. The 90Y radioactivity in the urine of the patients showed a positive correlation with the administration dose, while the 90Y radioactivity concentration exhibited a negative correlation with the urine volume. Conclusions The 90Y-labeled resin microsphere for the embolization treatment of liver tumors can cause high radioactivity and radioactivity concentration of 90Y in the urine of patients, necessitating appropriate treatment and enhanced radiological protection management in the ward. |
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