| 关子易,马丽萍,高玲.辐射对细胞干性转变的影响及机制研究进展[J].中华放射医学与防护杂志,2026,46(2):205-212.Guan Ziyi,Ma Liping,Gao Ling.Advances in research on effects of radiation on cell stemness transition and their mechanisms[J].Chin J Radiol Med Prot,2026,46(2):205-212 |
| 辐射对细胞干性转变的影响及机制研究进展 |
| Advances in research on effects of radiation on cell stemness transition and their mechanisms |
| 投稿时间：2025-07-28 |
| DOI：10.3760/cma.j.cn112271-20250728-00269 |
| 中文关键词: 电离辐射 干性相关基因 细胞干性转变 |
| 英文关键词:Ionizing radiation Stemness-related gene Cell stemness transition |
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| 中文摘要: |
| 电离辐射可通过DNA损伤与修复、干性相关信号的激活、表观遗传修饰等多种方式引起细胞干性转变,这种干性转变可影响细胞损伤和肿瘤发生。Wnt、Notch、Hedgehog干性相关基因参与辐射应答过程,Nanog、Oct4、Sox2和LGR5则直接参与细胞干性转变的调节。本文综述了细胞干性转变的生物学特性,以及干性相关基因在辐射诱导细胞干性转变中发挥的作用进展,从而为干性转变研究提供理论支持,为靶向干性基因干预辐射损伤提供理论依据。 |
| 英文摘要: |
| Ionizing radiation can induce cell stemness transition through multiple mechanisms, such as DNA damage and repair, activation of stemness-related signaling pathways, and epigenetic modifications. Such stemness transition can further affect cell injury and tumorigenesis. Specifically, stemness-related genes, such as Wnt, Notch, and Hedgehog, participate in radiation response, while transcription factors, including Nanog, Oct4, Sox2, and LGR5, are directly involved in the regulation of the cell stemness transition. This study reviews the biological characteristics of cell stemness transition, along with advances in research on the role of stemness-related genes in radiation-induced cell stemness transition. The purpose is to provide theoretical support and bases for both research on stemness transition and the targeted intervention of stemness-related genes for radiation-induced injury. |
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