| 朱红玉,胡安康,赖有方,等.FLASH照射的微观尺度蒙特卡罗模拟研究进展[J].中华放射医学与防护杂志,2025,45(11):1157-1164.Zhu Hongyu,Hu Ankang,Lai Youfang,et al.Research advances in microscopic Monte Carlo simulations of FLASH irradiation[J].Chin J Radiol Med Prot,2025,45(11):1157-1164 |
| FLASH照射的微观尺度蒙特卡罗模拟研究进展 |
| Research advances in microscopic Monte Carlo simulations of FLASH irradiation |
| 投稿时间：2025-07-08 |
| DOI：10.3760/cma.j.cn112271-20250708-00235 |
| 中文关键词: FLASH照射 蒙特卡罗模拟 放射生物学效应 |
| 英文关键词:FLASH irradiation Monte Carlo simulation Radiobiological effect |
| 基金项目:国家重点研发计划项目(2022YFC2402304);国家自然科学基金(12305410,12405359);广州市科技局基础与应用基础研究专题(优秀博士"续航"项目,2025A04J2004) |
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| 中文摘要: |
| FLASH照射是肿瘤放疗领域最前沿的研究方向之一。研究表明, FLASH照射可以有效杀伤肿瘤, 同时显著减少正常组织损伤, 展现出独特的高效、低毒的生物学效应。微观尺度蒙特卡罗模拟是研究放射生物学效应的重要方法, 已广泛应用于常规放射治疗研究。近年来, 其在FLASH照射的微观反应分析及机制探索方面的应用研究正在快速增长。本文系统综述了FLASH照射微观尺度蒙特卡罗模拟研究的最新进展及面临的挑战, 以期为未来相关研究提供理论参考与方法学指导。 |
| 英文摘要: |
| FLASH irradiation (FLASH-IR) is one of the cutting-edge research directions in the field of tumor radiotherapy. Previous studies have demonstrated that FLASH-IR can effectively eradicate tumors while significantly reducing damage to normal tissues, exhibiting unique biological effects characterized by high efficiency and low toxicity. Monte Carlo simulation at the microscopic scale is a critical method for studying radiobiological effects and has been widely applied in conventional radiotherapy research. In recent years, its application in microscopic reaction analysis and mechanistic exploration of FLASH-IR has grown rapidly. This article systematically reviews the latest advances and key challenges in microscopic Monte Carlo simulation studies of FLASH-IR, aiming to provide theoretical insights and method ological guidance for future research. |
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