| 中国医学装备协会放射治疗设备与技术分会.高能X射线FLASH照射临床前研究专家共识[J].中华放射医学与防护杂志,2025,45(11):1052-1060.Radiotherapy Equipment and Technology Branch of China Medical Equipment Association.Expert consensus on preclinical research into high-energy X-ray FLASH irradiation[J].Chin J Radiol Med Prot,2025,45(11):1052-1060 |
| 高能X射线FLASH照射临床前研究专家共识 |
| Expert consensus on preclinical research into high-energy X-ray FLASH irradiation |
| 投稿时间：2025-07-07 |
| DOI：10.3760/cma.j.cn112271-20250707-00229 |
| 中文关键词: 高能X射线 FLASH照射 临床前研究 实验操作流程 专家共识 |
| 英文关键词:High-energy X-ray FLASH irradiation Preclinical study Experimental procedure Expert consensus |
| 基金项目:国家自然科学基金(U2330122);四川省科技计划项目(2024ZDZX0027) |
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| 中文摘要: |
| FLASH技术是指剂量率≥ 40 Gy/s的照射, 与常规剂量率放疗相比, 可显著减轻正常组织损伤, 同时具备同样的肿瘤杀伤能力, 并且缩短了放疗时间。X-FLASH是一种全新的放疗技术, 为了加速其临床转化, 相关临床前研究数量快速增长, 但缺乏操作规范共识。本共识旨在建立一套标准化的X-FLASH临床前研究体系, 涵盖辐射剂量学、细胞、健康小鼠与荷瘤小鼠模型辐照等全流程规范, 为解析FLASH效应机制、验证设备性能及指导临床研究提供可复制的临床前研究操作流程。 |
| 英文摘要: |
| FLASH radiotherapy is a technique involving the delivery of irradiation at ultra-high dose rates (≥ 40 Gy/s). Compared to conventional dose rate radiotherapy (CONV), this technique can significantly reduce radiation-induced injury to normal tissues and the duration of radiotherapy while maintaining equivalent tumor-killing capacities. High-energy X-ray FLASH irradiation (X-FLASH), a novel radiotherapy, has seen a surge in the number of preclinical studies in an effort to accelerate its clinical translation. However, there is a lack of consensus regarding standardized experimental procedures. This study aims to establish a standardized preclinical research framework for X-FLASH that covers the entire experimental workflow, including ionizing radiation dosimetry, in vitro cell irradiation experiments, and irradiation models of both healthy and tumor-bearing mice for in vitro irradiation experiments. The purpose is to provide reproducible preclinical procedures for elucidating mechanisms underlying the FLASH effect, validating device performance, and guiding future clinical studies. |
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