中华放射医学与防护杂志

王文斐,田川,李学达,等.建立SPECT/CT探测γ射线光子计数值与¹²⁵I近距离治疗等剂量赋值模型[J].中华放射医学与防护杂志,2025,45(7):674-678.Wang Wenfei,Tian Chuan,Li Xueda,et al.Establishing an isodose assignment model for ¹²⁵I brachytherapy using γ-ray photon counts detected by SPECT/CT[J].Chin J Radiol Med Prot,2025,45(7):674-678

建立SPECT/CT探测γ射线光子计数值与¹²⁵I近距离治疗等剂量赋值模型

Establishing an isodose assignment model for ¹²⁵I brachytherapy using γ-ray photon counts detected by SPECT/CT

投稿时间：2024-07-30

DOI：10.3760/cma.j.cn112271-20240730-00290

中文关键词: SPECT/CT γ射线光子计数值剂量 ¹²⁵I 近距离治疗

英文关键词:SPECT/CT γ-ray photon count Dose ¹²⁵I Brachytherapy

基金项目:国家重点研发计划项目(2019YFE0120100)

作者	单位	E-mail
王文斐	青岛大学附属医院介入医学中心, 青岛 266003 胜利油田中心医院医学影像科, 东营 257099
田川	青岛大学附属医院介入医学中心, 青岛 266003
李学达	青岛大学附属医院介入医学中心, 青岛 266003
张宏涛	河北省人民医院肿瘤科, 石家庄 050051
王从晓	青岛大学附属医院介入医学中心, 青岛 266003
刘士锋	青岛大学附属医院介入医学中心, 青岛 266003
胡效坤	青岛大学附属医院介入医学中心, 青岛 266003	huxiaokun770@163.com
李腾	安徽大学人工智能学院, 合肥 230601

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中文摘要:

目的应用单光子发射计算机体层成像(SPECT)/CT对¹²⁵I距离治疗等剂量赋值,探究光子计数值与剂量值的对应关系,建立¹²⁵I近距离治疗γ射线可视化临床应用模型。方法将¹²⁵I放射性粒子填充至自制3D打印立体模板,完成立体模型设计。对模型进行SPECT/CT扫描并测量距离最外层周边粒子0.5、1.0、1.5、2.0 cm处光子计数值,对应放射性粒子治疗计划系统(TPS)中与其一一对应的剂量值。应用SPSS 27.0软件,得到光子计数值与剂量值的拟合关系。结果距外围粒子0.5、1.0、1.5、2.0 cm处γ射线光子计数值分别为7 603.57±1 806.35、4 018.26±1 315.72、2 074.04±791.53、1 080.34±424.79,组间差异有统计学意义(F=743.72,P<0.01)。距外围粒子0.5、1.0、1.5、2.0 cm处TPS中的剂量值(/Gy)为208.05±37.57、125.43±17.74、86.76±17.67、61.55±14.39,组间差异有统计学意义(F=930.46,P<0.01)。光子计数值与剂量值呈一元线性回归关系,方程式为y=0.02x+46.45(R²=81.2%,P<0.01)。结论通过SPECT/CT探测γ射线光子计数值,可以对应¹²⁵I近距离治疗剂量进行赋值,实现¹²⁵I近距离治疗γ射线可视化应用,具有较TPS的明显优势,从而为建立TPS的替代系统奠定理论基础。

英文摘要:

Objective To employ single-photon emission computed tomography (SPECT)/CT for isodose assignment in ¹²⁵I brachytherapy, assess the correlation between photon counts and dose values, and develop a clinical γ-ray visualization model for ¹²⁵I brachytherapy. Methods ¹²⁵I radioactive seeds were filled into a self-made 3D printed stereotactic template to build a stereotactic model. The model was scanned by SPECT/CT for photon counts at 0.5, 1.0, 1.5, 2.0 cm from the outermost peripheral seeds, and the corresponding dose values were measured using the Treatment Planning System (TPS). The fitting curve for the photon counts and the dose values was plotted using SPSS 27.0 software. Results The photon counts of γ rays at distances of 0.5, 1.0, 1.5, and 2.0 cm from the peripheral particles were 7 603.57±1 806.35, 4 018.26±1 315.72, 2 074.04±791.53, and 1 080.34±424.79, respectively, showing a significant difference (F=743.72, P<0.01). The dose values (in Gy) in the TPS at distances of 0.5, 1.0, 1.5, and 2.0 cm from the peripheral particles were 208.05±37.57, 125.43±17.74, 86.76±17.67, and 61.55±14.39, respectively, which were significantly different (F=930.46, P<0.01). The photon counts were linearly correlated with the dose values (y=0.02x+46.45, R²=81.2%, P<0.01). Conclusions SPECT/CT-based γ-ray photon count detection can be used to assign doses for ¹²⁵I brachytherapy, enabling the visualization of γ rays in ¹²⁵I brachytherapy. This approach has a distinct advantage over TPS, laying the foundation for the establishment of an alternative system to TPS.

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