| 魏鑫荻,陈维,王进,等.江苏省医用X射线诊断工作者队列1950—2021年死亡危险分析[J].中华放射医学与防护杂志,2025,45(7):655-662.Wei Xindi,Chen Wei,Wang Jin,et al.An analysis of deaths in medical X-ray diagnostic workers in Jiangsu province during 1950-2021[J].Chin J Radiol Med Prot,2025,45(7):655-662 |
| 江苏省医用X射线诊断工作者队列1950—2021年死亡危险分析 |
| An analysis of deaths in medical X-ray diagnostic workers in Jiangsu province during 1950-2021 |
| 投稿时间：2024-08-18 |
| DOI：10.3760/cma.j.cn112271-20240818-00308 |
| 中文关键词: 医用X射线诊断工作者 死亡危险 循环系统疾病 癌症 |
| 英文关键词:Medical diagnostic X-ray workers Risk of death Circulatory system diseases Carcinoma |
| 基金项目:中国医学科学院医学与健康科技创新工程(2021-I2M-1-042);江苏省医学重点学科(JSZJ20232201) |
| 作者 | 单位 | E-mail | | 魏鑫荻 | 南京医科大学公共卫生学院, 南京 211166 | | | 陈维 | 江苏省疾病预防控制中心放射防护所, 南京 210009 | | | 王进 | 南京医科大学公共卫生学院, 南京 211166
江苏省疾病预防控制中心放射防护所, 南京 210009 | jinwang@jscdc.cn | | 张子豪 | 南京医科大学公共卫生学院, 南京 211166 | | | 缪雨季 | 江苏省疾病预防控制中心放射防护所, 南京 210009 | | | 周媛媛 | 江苏省疾病预防控制中心放射防护所, 南京 210009 | | | 范向勇 | 江苏省疾病预防控制中心放射防护所, 南京 210009 | | | 王津晗 | 中国医学科学院放射医学研究所辐射损伤研究室, 天津 300192 | | | 顾叶青 | 中国医学科学院放射医学研究所辐射损伤研究室, 天津 300192 | |
|
| 摘要点击次数: 352 |
| 全文下载次数: 132 |
| 中文摘要: |
| 目的 研究长期接触职业X射线对人群各种疾病的死亡风险及其规律。方法 采用回顾性和前瞻性队列相结合的研究方法,选取1950—1980年间在江苏省医院放射科工作的医用X射线诊断工作者为放射组;同医院同时期未从事过放射工作的其他科室医务人员为对照组,形成调查队列。计算该队列1950—2011年间累计观察人年数,采用Cox回归模型,计算调整性别、到达年龄、出生年代和开始工作年代等因素后医用X射线诊断工作者的各种疾病的死亡风险。结果 该队列共完成随访6 953人,其中照射组3 649人,对照组3 304人,总观察人年数为347 362人年。截至2021年12月31日,该队列共死亡2 099人。Cox回归结果显示,与对照组相比,放射组中死亡危险显著增高的疾病有:全癌(RR=1.20,95%CI:1.04~1.39,Z=2.56,P<0.05;其中肺癌RR=1.52,95%CI:1.17~1.98,Z=3.10,P<0.01;胰腺癌RR=1.96,95%CI:1.11~3.46,Z=2.31,P<0.05);循环系统疾病(RR=1.29,95%CI:1.06~1.57,Z=2.58,P<0.01);内分泌、营养和代谢疾病(RR=1.90,95%CI:1.06~3.42,Z=2.14,P<0.05)。分层分析结果显示,男性工作者中,放射组全癌和肺癌的死亡风险增高(Z=3.50、2.92,P<0.01);开始工作年龄为26~30岁年龄组中,放射组循环系统疾病死亡风险增高(Z=2.06,P<0.05);到达年龄为61~岁年龄组中,放射组因全癌、肺癌和循环系统疾病死亡的风险增高(Z=2.90~4.31,P<0.01)。结论 江苏省医用X射线诊断工作者肺癌、胰腺癌、循环系统疾病的死亡危险升高,未来可进一步深入开展相关领域的研究。 |
| 英文摘要: |
| Objective To study the risk and pattern of deaths caused by various diseases in the population and in the case of long-term occupational X-ray exposure. Methods Using a combination of retrospective and prospective cohort research methods, an exposure group of medical X-ray diagnostic workers who worked in the radiology department of Jiangsu Provincial Hospital between 1950 and 1980 and a control group of medical workers from other departments who did not work with radiolog during the same period in the same hospital were selected to form a study cohort. The cumulative number of person years of observation in the cohort during 1950-2011 was calculated, and the Cox regression model was used to calculate the risk of deaths of medical X-ray diagnostic workers for various diseases through adjusting sex, attained age, birth age, and starting working age. Results A total of 6 953 follow-up visits was completed to the cohort, including 3 649 in the radiation group and 3 304 in the control group, with a total of 347 362 person years of observation. There were 2 099 deaths in the cohort as of December 31, 2021. Cox regression results showed that diseases with a significantly higher risk of death in the radiation group compared with the control group were: all-cancer (R=1.20, 95%CI: 1.04-1.39, Z=2.56, P<0.05, including lung cancer R=1.52, 95%CI: 1.17-1.98, Z=3.10, P<0.01, and pancreatic cancer R=1.96, 95%CI: 1.11-3.46, Z=2.31, P<0.05); diseases of the circulatory system (R=1.29, 95%CI: 1.06-1.57, Z=2.58, P<0.01); endocrine, nutritional and metabolic diseases (R=1.90, 95%CI: 1.06-3.42, Z=2.14, P<0.05). Stratified analyses showed that, of male workers, the radiation group had an increased risk of death caused by all-cancer and lung cancer (Z=3.50, 2.92, P<0.01); of the age group at starting ages 26 to 30, the radiation group had an increased risk of death distributed to circulatory diseases (Z=2.06, P<0.05); and in the age group at attained ages elder than 61 years, the radiation group had an increased risk of death distributed to all cancers, lung cancer, and circulatory diseases (Z=2.90-4.31, P<0.01). Conclusions As has been shown, threre is an increasing risk of death distributed to lung cancer, pancreatic cancer, and circulatory diseases in medical X-ray diagnostic workers in Jiangsu province. Further in-depth research in related areas may be conducted in the future. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|