中华放射医学与防护杂志

张佳,阮健磊,李小亮,等.氡温泉周围居民外周血circRNAs表达分析[J].中华放射医学与防护杂志,2025,45(3):178-182.Zhang Jia,Ruan Jianlei,Li Xiaoliang,et al.Analysis of circRNAs expression in peripheral blood of residents around radon hot springs[J].Chin J Radiol Med Prot,2025,45(3):178-182

氡温泉周围居民外周血circRNAs表达分析

Analysis of circRNAs expression in peripheral blood of residents around radon hot springs

投稿时间：2024-06-28

DOI：10.3760/cma.j.cn112271-20240628-00244

中文关键词: 氡温泉外周血环状RNAs 累积剂量

英文关键词:Radon hot spring Peripheral blood circRNAs Cumulative doses

基金项目:

作者	单位	E-mail
张佳	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088
阮健磊	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088
李小亮	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088
刘建香	中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室, 北京 100088	liujianxiang@nirp.chinacdc.cn

摘要点击次数: 1518

全文下载次数: 703

中文摘要:

目的分析氡温泉对其周围居民外周血环状RNAs(circRNAs)表达的影响。方法选取四川省某氡温泉周围居民51人作为氡温泉组,选取非氡温泉周围居民51人作为对照组。通过问卷调查收集两组研究对象的人口统计学资料及居民氡暴露程度的资料,实时荧光定量聚合酶链式反应(qRT-PCR)检测两组人群外周血候选circRNAs的相对表达水平,比较两组间circRNAs相对表达水平的差异。结果氡温泉组人均氡暴露累积剂量E_c为(111.47±99.03)mSv, 范围为3.32~458.68 mSv,与对照组相比,两组间 hsa_circ_0040573 相对表达量差异具有统计学意义(Z=-2.88,P<0.05)。氡暴露会抑制 hsa_circ_0040573 表达(t=-2.52,P<0.05),暴露程度可能影响其表达量(H=12.21,P<0.05)。结论 hsa_circ_0040573 有作为氡温泉暴露的辐射响应生物标志物的潜力,有助于早期诊断和监测与氡暴露相关的健康风险。

英文摘要:

Objective To investigate the effect of circular RNAs (circRNAs) expressions in peripheral blood of residents around radon hot springs. Methods Totally 51 residents around radon hot springs were selected as the radon hot sping group, and another 51 residents around non-radon hot springs were selected as the control group. Questionnaires were used to collect demographic information and the radon exposure levels in the two groups. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expressions of selected circRNA candidates in peripheral blood of the two groups. Mann-Whitney U test was used to compare the differences in the relative expressions of the circRNAs between the two groups. Results The cumulative doses of radon exposure per capita for residents around radon hot springs was (111.47±99.03) mSv, with dose range 3.32-458.68 mSv. The difference in the relative expressions of hsa_circ_0040573 between the two groups was statistically significant (Z= -2.88, P< 0.05). The expression of hsa_circ_0040573 was suppressed by radon exposure (t= -2.52, P< 0.05) with a dose-dependent manner (H= 12.21, P< 0.05). Conclusion Hsa_circ_0040573 has a potential to serve as a radiological response biomarker for radon exposure, contributing to early diagnosis and monitoring of health risks associated with radon exposure.

HTML 查看全文查看/发表评论下载PDF阅读器

关闭