| 朱雅迪,高军,季翔,等.拓展准直器对硼中子俘获治疗束流特性的影响研究[J].中华放射医学与防护杂志,2024,44(7):601-607.Zhu Yadi,Gao Jun,Ji Xiang,et al.Research on the impact of the extended collimator on the beam characteristics of the boron neutron capture therapy[J].Chin J Radiol Med Prot,2024,44(7):601-607 |
| 拓展准直器对硼中子俘获治疗束流特性的影响研究 |
| Research on the impact of the extended collimator on the beam characteristics of the boron neutron capture therapy |
| 投稿时间：2024-01-19 |
| DOI：10.3760/cma.j.cn112271-20240119-00026 |
| 中文关键词: 硼中子俘获治疗 拓展准直器 束流分布 |
| 英文关键词:Boron neutron capture therapy Extended collimator Beam distribution |
| 基金项目:重庆市自然科学基金项目资助(CSTB2023NSCQ-BSX0014) |
| 作者 | 单位 | E-mail | | 朱雅迪 | 中国科学院合肥物质科学研究院, 合肥 230031
中国科学技术大学, 合肥 230026 | | | 高军 | 山东省中子科学技术重点实验室, 青岛 266199
中子科学研究院(重庆)有限公司, 重庆 401331
中子科学国际研究院, 青岛 266199 | | | 季翔 | 山东省中子科学技术重点实验室, 青岛 266199
中子科学研究院(重庆)有限公司, 重庆 401331
中子科学国际研究院, 青岛 266199 | | | 廉超 | 山东省中子科学技术重点实验室, 青岛 266199
中子科学研究院(重庆)有限公司, 重庆 401331
中子科学国际研究院, 青岛 266199 | | | 王永峰 | 山东省中子科学技术重点实验室, 青岛 266199
中子科学研究院(重庆)有限公司, 重庆 401331
中子科学国际研究院, 青岛 266199 | | | 高胜 | 山东省中子科学技术重点实验室, 青岛 266199
中子科学研究院(重庆)有限公司, 重庆 401331
中子科学国际研究院, 青岛 266199 | sheng.gao@fds.org.cn |
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| 中文摘要: |
| 目的 在硼中子俘获治疗(BNCT)的常规准直器基础上设计了拓展准直器,分析不同准直器情况下患者模体的束流分布特性。方法 采用蒙特卡罗方法模拟,计算了常规准直器、5 cm长拓展准直器、10 cm长拓展准直器沿着束流方向的中子束流分布;选取10 cm长拓展准直器无间隙的情况,模拟计算了不同质量百分比的氟化锂(LiF)与聚乙烯材料组合、碳化硼(B4C)与聚乙烯材料组合的照射时间和优势深度;分别模拟计算了常规准直器下和拓展准直器下无间隙及其他不同间隙对照射时间、优势深度及离轴剂量的影响。结果 10 cm长度拓展准直器无间隙情况,热中子通量密度、伽马射线剂量率以及快中子剂量率最大,其峰值分别为1.0×109 n/(cm2·s)、5.3 cGy/min、9.1 cGy/min;相较于聚乙烯结合B4C,聚乙烯结合LiF的准直器材料在优势深度和照射时间均有优势;对于5种聚乙烯结合LiF的准直器材料,优势深度最大的是20 wt%聚乙烯结合80 wt%LiF的材料,为8.7 cm,然而其照射时间较长,为20.5 min;照射时间最短的为80 wt%聚乙烯结合20 wt%LiF的材料,仅为19.0 min,其优势深度为8.5 cm;对于不同准直器长度、不同空气间隙的剂量分布,相比不使用拓展准直器的情况,5、10 cm长度拓展准直器能够分别降低26.4%、40.3%的治疗时间,同时优势深度变化较小;同一准直器情况下,随着空气间隙的增大,离轴剂量则越大。结论 5、10 cm长度拓展准直器的使用,能够在提高中子束流强度、降低照射时间的同时,对优势深度、离轴剂量等参数影响较小,从而能够解决由于头颈部活动受限等情况下患者肿瘤体表与出束口存在空气间隙所导致的治疗时间增长的问题。BNCT装置可结合实际临床需求,采用适用的拓展准直器。 |
| 英文摘要: |
| Objective To investigate beam distribution characteristics through a phantom with conventional or extended collimators designed based on conventional collimators in boron neutron capture therapy (BNCT). Methods By Monte Carlo simulation, we calculated the neutron beam distributions along the beam direction with a conventional collimator, 5 cm-extended collimator, and 10 cm-extended collimator; calculated the irradiation time and average depth using 10 cm-extended collimators with no air gap comprised of lithium fluoride (LiF)+polyethylene or boron carbide (B4C)+polyethylene at different mass ratios; and calculated the irradiation time, advantage depth, and off-axis dose with conventional or extended collimators at without air gap or certain air gaps. Results For the 10 cm-extended collimator without air gap, the thermal neutron flux density, gamma ray dose rate, and fast neutron dose rate were highest, and their peaks were 1.0×109 n/(cm2·s), 5.3 cGy/min, and 9.1 cGy/min, respectively. Collimators comprised of polyethylene and LiF were superior to those of polyethylene and B4C in advantage depth and irradiation time. For five types of collimators made of polyethylene and LiF, the combination of 20 wt% polyethylene and 80 wt% LiF exhibited the greatest advantage depth (8.7 cm), but with a longer irradiation time (20.5 minutes); and the combination of 80 wt% polyethylene and 20 wt% LiF achieved the shortest irradiation time (19.0 minutes), with an advantage depth of 8.5 cm. Compared with the conventional collimator, the use of 5 cm- and 10 cm-extended collimators reduced treatment time by 26.4% and 40.3%, respectively, with small changes in advantage depth; and for the same collimator, the off-axis dose increased with the increase in the air gap. Conclusions The use of 5 cm- and 10 cm-extended collimators can increase neutron beam intensity and reduce irradiation time, with a small impact on advantage depth and off-axis dose, which can solve the problem of prolonged treatment time caused by an air gap between patient's tumor surface and the beam aperture when head and neck movement is limited. BNCT can be equipped with appropriate extended collimators according to actual clinical needs. |
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