陈亮,梁译尹,张巍巍,童姣姣,张火俊.类器官在肿瘤放射治疗相关研究中的应用进展[J].中华放射医学与防护杂志,2024,44(6):543-548
类器官在肿瘤放射治疗相关研究中的应用进展
Advances in application of organoids to research on radiotherapy of tumors
投稿时间:2023-11-03  
DOI:10.3760/cma.j.cn112271-20231103-00158
中文关键词:  类器官  放射治疗  实验模型  个性化治疗  放疗增敏
英文关键词:Organoids  Radiotherapy  Experimental model  Personalized therapy  Radiotherapy sensitization
基金项目:上海卫生健康委员会领军人才计划(2022LJ019); 国家自然科学基金面上项目(82272742); 科技部国家重点研发计划(2022YFC2503701, FW-ZXKT2022102502004); 长海医院"固海"计划(GH145-33).
作者单位E-mail
陈亮 海军军医大学附属长海医院放射治疗科, 上海 200433  
梁译尹 海军军医大学附属长海医院放射治疗科, 上海 200433  
张巍巍 海军军医大学附属长海医院放射治疗科, 上海 200433  
童姣姣 海军军医大学附属长海医院放射治疗科, 上海 200433  
张火俊 海军军医大学附属长海医院放射治疗科, 上海 200433 chyyzhj@163.com 
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中文摘要:
      类器官是一种体外培养的三维微型结构,源自健康个体或患者的人多能干细胞或成体干细胞。相对于传统的细胞系或动物模型,类器官被视为更有前途的高保真模型,在疾病建模、药物开发、建立活体生物库和探索个性化治疗方面具有独特的优势。近年来,类器官技术的飞速发展为革新肿瘤临床前实验模型和推动临床个性化诊疗带来了新希望。本综述旨在介绍类器官在肿瘤放射治疗领域的发展现状和最新进展,讨论癌症类器官模型的优势和局限,并对其在放射治疗领域的应用前景进行展望。
英文摘要:
      Organoids are in vitro-cultured three-dimensional (3D) miniature structures derived from human pluripotent stem cells or adult stem cells from healthy individuals or patients. Compared to traditional two-dimensional (2D) cell lines or animal models, organoids are regarded as more promising high-fidelity models, possessing unique advantages in terms of disease modeling, drug development, the establishment of living biobanks, and the exploration of personalized treatment. Over recent years, the rapid development of organoid technology has brought new hopes for innovating preclinical experimental tumor models and promoting clinical personalized diagnosis and treatment. This review is intended to introduce the development status and latest progress of organoids in the field of radiotherapy for tumors, explore the advantages and limitations of organoid models for cancer, and prospect for its application in the field of radiotherapy.
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