| 冯阳,曹建平,焦旸.RNA m6A甲基化修饰在肿瘤放疗和辐射损伤修复中的关键作用[J].中华放射医学与防护杂志,2023,43(7):559-563.Feng Yang,Cao Jianping,Jiao Yang.The key role of RNA N6-methyladenosine (m6A) methylation in tumor radiotherapy and radiation damage repair[J].Chin J Radiol Med Prot,2023,43(7):559-563 |
| RNA m6A甲基化修饰在肿瘤放疗和辐射损伤修复中的关键作用 |
| The key role of RNA N6-methyladenosine (m6A) methylation in tumor radiotherapy and radiation damage repair |
| 投稿时间：2022-12-06 |
| DOI：10.3760/cma.j.cn112271-20221206-00471 |
| 中文关键词: m6A甲基化修饰|m6A甲基转移酶|去甲基化酶|甲基化识别酶|辐射损伤修复 |
| 英文关键词:N6-methyladenosine modification(m6A)|m6A methyltransferase (Writers)|m6A demethylase (Erasers)|m6A methylation recognition enzymes (Readers)|Radiation-induced injuries |
| 基金项目:国家自然科学基金(U1967220,81773226);国家重点研发计划项目(2022YFC2503700,2022YFC2503703) |
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| 中文摘要: |
| N6-甲基腺苷(N6-methyladenosine, m6A)是真核信使RNA (mRNA)中最丰富的表观遗传学修饰。m6A甲基化修饰的发生由m6A甲基转移酶(Writers)催化;通过去甲基化酶(Erasers)去除;此外,m6A甲基化修饰被甲基化识别酶(Readers)识别。m6A甲基化修饰可调节RNA的剪接、翻译和稳定性。m6A甲基化修饰参与细胞活动中多种重要功能基因的生物学调控,重要的是,m6A水平异常变化可影响肿瘤的发生、发展、转移以及复发等过程。电离辐射对m6A水平及m6A甲基化修饰相关酶的水平产生影响。在肿瘤放射治疗过程中,m6A修饰通过影响DNA损伤、肿瘤细胞辐射敏感性等,进而影响放射治疗疗效。此外,电离辐射影响m6A甲基化水平,进而调控辐射损伤修复等过程。本文就RNA的m6A甲基化修饰在肿瘤放疗和辐射损伤修复中作用机制的研究进展进行综述,旨在为临床肿瘤放射增敏剂及放射防护剂的研发提供新的思路。 |
| 英文摘要: |
| N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic messenger RNA (mRNA), which could be catalyzed by m6A methyltransferase (Writers), recognized by methylation recognition enzymes (Readers), and removed by demethylase (Erasers). RNA splicing, translation, and stability could be modulated by m6A methylation modification. The m6A methylation modification is involved in the biological regulation of a variety of important functional genes in cellular activities. Importantly, abnormal m6A modification affects the occurrence, development, metastasis and recurrence of tumors. Ionizing radiation can affect the level of m6A and m6A methylation-related enzymes. Recently, m6A methylation is reported to regulate the efficacy of tumor radiotherapy by affecting DNA damage and radiosensitivity of tumor cells. In addition, ionizing radiation can also affect the level of m6A modification in normal cells to regulate the progress of radiation-induced injuries. This review summarizes the research progress on the roles of m6A methylation in tumor radiosensitivity and radiation-induced injuries, with the aim of providing novel strategies for the development of clinical tumor radiosensitizers and radioprotective agents. |
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