| 吴凡,唐斌,杨凤,等.三种验证设备在立体定向放射治疗的剂量验证结果分析[J].中华放射医学与防护杂志,2022,42(9):678-684.Wu Fan,Tang Bin,Yang Feng,et al.Analysis of dosimetric verification results of three verification systems for stereotactic body radiation therapy[J].Chin J Radiol Med Prot,2022,42(9):678-684 |
| 三种验证设备在立体定向放射治疗的剂量验证结果分析 |
| Analysis of dosimetric verification results of three verification systems for stereotactic body radiation therapy |
| 投稿时间：2022-06-24 |
| DOI：10.3760/cma.j.cn112271-20220624-00267 |
| 中文关键词: 立体定向放射治疗 剂量验证 靶区体积 计算网格 剂量阈值 |
| 英文关键词:Stereotactic body radiation therapy Dosimetric verification Target volume Calculation grid size Dose threshold |
| 基金项目:四川省重点研发项目(2021YFG0168,2021YFG0320,2022YFS0047);肿瘤医工创新基金(ZYGX2021YGCX002) |
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| 中文摘要: |
| 目的 比较靶区体积、计算网格和剂量阈值等参数对ArcCHECK、SRS MapCHECK和3DMap 3种验证设备的立体定向放射治疗剂量验证结果的影响。方法 选取50例立体定向放疗计划,分别比较靶区体积(<25 cm3和≥25 cm3)、计算网格(1.0、1.5和2.0 mm)和剂量阈值(5%、10%和15%)对3种验证设备3 mm/3%、3 mm/2%、3 mm/1%、2 mm/3%和 2 mm/2%的γ通过率的影响。结果 靶区体积的改变对于3DMap的影响较大,与小体积相比,3DMap大体积的3 mm/3%、3 mm/2%、2 mm/3%和2 mm/2%的γ通过率分别增加2.2%、2.2%、4.4%和4.7%(t=-2.76、-2.17、-4.72、-3.86,P<0.05);计算网格1.5和1.0 mm相比,对于MapCHECK的影响较大,5种γ通过率分别降低0.7%、1.1%、1.7%、0.9%和1.5%(t=-6.15、 -6.23、-5.98、-5.11、-8.34,P<0.05)。计算网格2.0和1.0 mm相比,对于ArcCHECK影响较大,5种γ通过率分别降低1.0%、1.7%、2.4%、1.7%和2.7%(t=-4.75、-7.30、 -8.63、 -7.11、-8.26,P<0.05);剂量阈值10%和5%相比,对于ArcCHECK影响较大,3 mm/3%、 3 mm/2%、2 mm/3%和2 mm/2%的γ通过率分别降低0.5%、0.8%、1.2%和1.7% (t=5.20、5.68、8.17、9.99,P<0.05)。剂量阈值15%和5%相比,对于3DMap的影响较大,3 mm/3%、 3 mm/2%、2 mm/3%和2 mm/2%的γ通过率分别降低1.6%、1.7%、2.8%和3.2%(t=3.25、2.98、4.40、4.21,P<0.05)。结论 靶区体积、计算网格和剂量阈值对3种验证设备立体定向放疗计划的验证通过率产生不同程度的影响。在临床使用时应对于不同的验证设备具体考虑这些参数对于验证结果的影响。 |
| 英文摘要: |
| Objective To compare the effects of parameters,such as planning target volume (PTV),calculation grid size,and dose threshold,on the dosimetric verification result of three dosimetric verification systems ArcCHECK,SRS MapCHECK,and 3DMap for stereotactic body radiation therapy (SBRT).Methods Based on the dosimetric verification result of the SBRT plans of 50 patients,this study compared the effects of PTV (<25 cm3 and ≥ 25 cm3),calculation grid size (1.0,1.5,and 2.0 mm),and dose threshold (5%,10%,and 15%) on the γ passing rates of the three dosimetric verification systems at five criteria,i.e.,3 mm/3%,3 mm/2%,3 mm/1%,2 mm/3%,and 2 mm/2%.Results The changes in PTV affected 3DMap more significantly.With an increase in PTV,the γ passing rates of 3DMap at the criteria of 3 mm/3%,3 mm/2%,2 mm/3%,and 2 mm/2% increased by 2.2%,2.2%,4.4%,and 4.7%(t=-2.76,-2.17,-4.72,-3.86,P<0.05),respectively.The increase in the calculation grid from 1.0 mm to 1.5 mm had greater effect on MapCHECK,with the γ passing rates at the criteria of 3 mm/3%,3 mm/2%,3 mm/1%,2 mm/3% and 2 mm/2% decreased by 0.7%,1.1%,1.7%,0.9%,1.5%(t=-6.15,-6.23,-5.98,-5.11,-8.34,P<0.05),respectively.The increases in the calculation grid from 1.0 mm to 2.0 mm had greater impact on ArcCHECK,with the γ passing rates at the criteria of 3 mm/3%,3 mm/2%,3 mm/1%,2 mm/3%,2 mm/2% decreased by 1.0%,1.7%,2.4%,1.7%,2.7%(t=-4.75,-7.3,-8.63,-7.11,-8.26,P<0.05),respectively.The increase in the dose threshold from 5% to 10% had greater impact on ArcCHECK,with the γ passing rates at the criteria of 3 mm/3%,3 mm/2%,2 mm/3% and 2 mm/2% decreased by 1.1%,1.4%,2.5%,and 3.0%(t=5.20,5.68,8.17,9.99,P<0.05),respectively.Moreover,the increase in the dose threshold from 5% to 15% had more impact on 3DMap,with the γ passing rates at the criteria of 3 mm/3%,3 mm/2%,2 mm/3%,and 2 mm/2% decreased by 1.6%,1.7%,2.8%,and 3.2%(t=3.25,2.98,4.40,4.21,P<0.05),respectively.Conclusions Target volume,calculation grid,and dose threshold are influencing factors in the dosimetric verification of three dosimetric verification systems for SBRT.Therefore,the effects of these parameters should be considered for different verification systems in clinical applications. |
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