| 李洪均,刘娜,张建萍,于鸿煦,刘雪辉,王俊杰.3D打印模板联合CT引导125I粒子植入治疗骨转移癌术前术后剂量学评价[J].中华放射医学与防护杂志,2021,41(10):735-740 |
| 3D打印模板联合CT引导125I粒子植入治疗骨转移癌术前术后剂量学评价 |
| Dosimetry verfication between pre and post operation of 3D-printing template assisted by CT-guided 125I seed implantation in the treatment of bone metastases |
| 投稿时间：2021-02-07 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.10.003 |
| 中文关键词: 3D打印模板 放射性粒子植入 骨转移癌 近距离放疗 放射治疗剂量 |
| 英文关键词:3D-printing template Radioactive seed implantation Bone metastases Brachytherapy Radiotherapy dose |
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| 中文摘要: |
| 目的 对比分析3D打印模板联合CT引导125I粒子植入治疗骨转移癌术前术后常用剂量学指标差异，指导临床应用。方法 对2019年6月至2021年1月天津市第三中心医院骨转移癌粒子植入手术的10例患者共12个病灶进行回顾性分析，12个病灶均采用3D打印模板引导粒子植入，处方剂量120~140 Gy，比较术前治疗计划及术后验证计划中常用剂量学指标差异，包括D90、D100、V90、V100、V150以及术前计划粒子数量和术后实际使用粒子数量，采用配对t检验对术前术后剂量参数进行对比分析。结果 术前和术后D90、D100、V90、V100、V150等剂量学指标差异均无统计学意义（P>0.05），术后实际使用粒子数量多于术前计划，差异有统计学意义（t=-2.930，P<0.05）。结论 3D打印模板联合CT引导125I粒子植入治疗骨转移癌，剂量精准，可达到术前计划要求，应积极推广临床使用。 |
| 英文摘要: |
| Objective To compare and analyze the differences of common dose indicators before and after operation of 3D-printing template assisted by CT-guided 125I seed implantation in the treatment of bone metastases to guide clinical application. Methods A retrospective analysis of 12 lesions in the 10 patients (9 males and 1 female, median age 65 years), who underwent seed implantation surgery for bone metastases in the Tianjin Third Central Hospital from June 2019 to January 2021, was conducted. All the lesions were adopted for 3D-printing template to guide seed implantation and the prescribed dose was 120-140 Gy. The differences of common dose indicators between preoperative treatment plan and postoperative verification plan were compared, including D90 (dose received by 90% of the target volume), D100 (dose received by 100% of the target volume), V90 (the volume percent for tumor target volume receiving 90% of the prescribed dose), V100 (the volume percent for tumor target volume receiving 100% of the prescribed dose), V150 (the volume percent for tumor target volume receiving 150% of the prescribed dose), as well as the quantity of seeds planned and actually used. The paired t-test was performed to compare and analyze those parameters. Results There was no statistically significant difference in pre- and postoperative D90, D100, V90, V100, V150 (P > 0.05). The actual quantity of seeds used after operation was more than that of the preoperative planned quantity and the difference was statistically significant (t=-2.930, P < 0.05). Conclusions The clinical use of 3D-printing template assisted by CT-guided 125I seed implantation for bone metastasis should be promoted since the dose is accurate and the requirements of preoperative plan can be achieved. |
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