| 徐笛,张玉财,周琪怡,等.肿瘤硼中子俘获治疗的理论基础与近期研究进展[J].中华放射医学与防护杂志,2021,41(1):74-77.Xu Di,Zhang Yucai,Zhou Qiyi,et al.Boron neutron capture therapy of cancers: principles and recent research progress[J].Chin J Radiol Med Prot,2021,41(1):74-77 |
| 肿瘤硼中子俘获治疗的理论基础与近期研究进展 |
| Boron neutron capture therapy of cancers: principles and recent research progress |
| 投稿时间：2020-10-15 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.015 |
| 中文关键词: 硼中子俘获治疗 中子源 硼递送剂 肿瘤 |
| 英文关键词:Boron neutron capture therapy Neutron sources Boron delivery agents Cancer |
| 基金项目:国家自然科学基金（31600805）；江苏省自然科学基金（BK20160329） |
|
| 摘要点击次数: 4234 |
| 全文下载次数: 2034 |
| 中文摘要: |
| 硼中子俘获治疗（BNCT）是一种新型肿瘤精准治疗方法，通过肿瘤细胞内的10B俘获热中子发生核裂变反应产生α粒子和反冲7Li核选择性地杀死肿瘤细胞。将足量的10B选择性递送到肿瘤细胞内部是BNCT成功的关键。本文简要介绍了BNCT治疗肿瘤的理论基础，综述了BNCT所用的中子源和硼递送剂的近期研究进展，简述了BNCT临床治疗试验结果。 |
| 英文摘要: |
| Boron neutron capture therapy (BNCT) is a new method for the precise treatment of cancers.By this method, cancer cells can be selectively killed by α particles and recoiling 7Li nuclei generated by the nuclear fission reaction occurring when the 10B isotope atoms in cancer cells capture thermal neutrons.The key to a successful BNCT is to deliver sufficient 10B into the cancer cells.The purpose of this review is to introduce the principles of BNCT and review recent progress in the development of neutron sources and boron delivery agents, as well as the result of BNCT clinical trials. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |